MT-ND6 Rabbit pAb(bs-3955R)-50ul/100ul/200ul
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MT-ND6 Rabbit pAb(bs-3955R)-50

ul/100ul/200ul
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  • ￥1180 - 2800
  • Bioss已认证
  • bs-3955R
  • 2025年10月25日
  • 产品信息以Bioss网站为准
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北京博奥森生物技术有限公司
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      50ul/100ul/200ul

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    规格：200ul产品价格：￥2800.0
    产品编号bs-3955R
    英文名称MT-ND6 Rabbit pAb
    中文名称NADH复合体6抗体
    英文别名Mitochondrially encoded NADH dehydrogenase 6; NADH-ubiquinone oxidoreductase chain 6; MT ND6; mtND6; NADH dehydrogenase subunit 6(complex I); NADH dehydrogenase subunit 6; NADH ubiquinone oxidoreductase chain 6; NADH Ubiquinone Oxidoreductase subunit ND6; NADH6; ND6; NU6M_HUMAN; NU6M_HUMAN.
    产品应用IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, Flow-Cyt=1ug/Test

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Human, Rat (Mouse, Dog, Cow, Horse, Sheep)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human MTND6
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量19 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cancer > Cancer Metabolism > Metabolic signaling pathway > Integration of energy metabolism

    Metabolism > Pathways and Processes > Metabolic signaling pathways > Energy transfer pathways > Integration of energy

    Metabolism > Pathways and Processes > Mitochondrial Metabolism > Mitochondrial markers

    Metabolism > Pathways and Processes > Mitochondrial Metabolism > Oxidative phosphorylation > Complex I

    Neuroscience > Sensory System > Visual system

    Signal Transduction > Metabolism > Mitochondrial

    亚细胞定位Mitochondrion membrane; Multi-pass membrane protein (Potential).
    相似性Belongs to the complex I subunit 6 family.
    功能Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料NADH Dehydrogenase subunit 6 (MTND6) is 1 of the 7 mitochondrial DNA (mtDNA) encoded subunits (MTND1, MTND2, MTND3, MTND4L, MTND4, MTND5, MTND6) included among the approximately 41 polypeptides of respiratory Complex I. Complex I accepts electrons from NADH, transfers them to ubiquinone (Coenzyme Q10), and uses the energy released to pump protons across the mitochondria inner membrane. MTND6 has been proposed to be a component of the iron-protein fragment.

     

    应用推荐稀释比例
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}
    {IF}{1:100-500}
    {Flow-Cyt}{1ug/Test}

     

    MT-ND6 Rabbit pAb(bs-3955R)-50
    Blank control: THP-1.
    Primary Antibody (green line): Rabbit Anti-MT-ND6 antibody (bs-3955R)
    Dilution: 1μg /10^6 cells;
    Isotype Control Antibody (orange line): Rabbit IgG .
    Secondary Antibody : Goat anti-rabbit IgG-FITC
    Dilution: 0.5μg /test.
    Protocol
    The cells were fixed with 4% PFA (10min at room temperature)and then permeabilized with 0.1% PBST for 20 min at room temperature. The cells were then incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.
    MT-ND6 Rabbit pAb(bs-3955R)-50
    P‌‌araformaldehyde-fixed, paraffin embedded (rat brain tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (MT-ND6) Polyclonal Antibody, Unconjugated (bs-3955R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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    图标文献和实验
    该产品被引用文献

    [IF={{ 5.2 }}] {Wu, Ji-hong, et al. "Cumulative mtDNA damage and mutations contribute to the progressive loss of RGCs in a rat model of glaucoma." Neurobiology of Disease (2014).} {WB} {="Rat"}

    [IF={{ 4.3 }}] {Ruyuan Wang. et al. Mitochonic acid 5 increases boar sperm quality by mitigating mitochondrial dysfunction. FRONT CELL DEV BIOL. 2025 Jun;13:1583951} {WB} {Pig}

    [IF={{ 4.1 }}] {Derya Erisik. et al. Differences and Similarities between Colorectal Cancer Cells and Colorectal Cancer Stem Cells: Molecular Insights and Implications. ACS OMEGA. 2023;XXXX(XXX):XXX-XXX} {ICC} {Human}

    [IF={{ 3 }}] {Ruyuan Wang. et al. Mitochonic Acid 5 Increases Ram Sperm Quality by Improving Mitochondrial Function during Storage at 4 °C. ANIMALS. 2024 Jan;14(3):368} {WB} {Sheep}

    [IF={{ 15.84 }}] {Ke Cao. et al. Hypermethylation of Hepatic Mitochondrial ND6 Provokes Systemic Insulin Resistance. 2021 May 02} {WB} {Mouse}

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    文献支持
    MT-ND6 Rabbit pAb(bs-3955R)-50ul/100ul/200ul
    ￥1180 - 2800