- ￥1180 - 2800
- Bioss
- bs-24137R
- 2025年10月24日
- 产品信息以Bioss网站为准
企业认证
相关产品推荐更多 >
phospho-BAD (Ser128) Rabbit pAb, Cy7 conjugated(bs-0893R-Cy7)-100ul
￥2980
SPINK1 Rabbit pAb(bs-2916R)-50ul/100ul/200ul
￥1180IGF2R/M6PR Rabbit pAb, PE-Cy7 conjugated(bs-6670R-PE-Cy7)-100ul
￥2980phospho-beta Actin (Tyr53) Rabbit pAb, BF594 conjugated(bs-12581R-BF594)-100ul
￥2980SLC25A3 Rabbit pAb, FITC conjugated(bs-19814R-FITC)-100ul
￥2980
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 应用范围：
产品信息以Bioss网站为准
- 规格：
50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-24137R |
| 英文名称 | SGOL2 Rabbit pAb |
| 中文名称 | SGOL2蛋白抗体 |
| 英文别名 | Sgo2; Sgol2; SGOL2_HUMAN; Shugoshin-2; Shugoshin-like 2; Tripin. |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500 Not yet tested in other applications. |
| 交叉反应 | Mouse |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from mouse SGOL2 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 145 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cell Biology > Cell Cycle > Cell Division > Centromere Epigenetics and Nuclear Signaling > Cell cycle > Chromosome Structure > Centromere Epigenetics and Nuclear Signaling > Chromosome Structure > Cohesins |
| 亚细胞定位 | Nucleus. Chromosome > centromere. Chromosome > centromere > kinetochore. During meiosis I, accumulates at centromeres during diplotene, and co-localizes differentially with the cohesin subunits RAD21 and REC8 at metaphase I centromeres. SGO2 and RAD21 change their relative distributions during telophase I when sister-kinetochore association is lost. During meiosis II, it shows a striking tension-dependent redistribution within centromeres throughout chromosome congression during prometaphase II, as it does during mitosis (By similarity). In Hela cells, localizes at centromeres throughout prophase until metaphase and disappears at anaphase. Centromeric localization requires the presence of BUB1 and AUKRB. |
| 翻译后修饰 | Phosphorylated upon DNA damage, probably by ATM or ATR. |
| 相似性 | Belongs to the shugoshin family. |
| 功能 | Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | SGO2 (Shugoshin 2) is a Protein Coding gene. Diseases associated with SGO2 include Perrault Syndrome. Among its related pathways are Mitotic Metaphase and Anaphase and Signaling by GPCR. |
| 应用 | 推荐稀释比例 |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
Paraformaldehyde-fixed, paraffin embedded (Mouse testis); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (SGOL2) Polyclonal Antibody, Unconjugated (bs-24137R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验该产品被引用文献
[IF={{ 3.3 }}] {Yinghua Chen. et al. SGO2 as a Prognostic Biomarker Correlated with Cell Proliferation, Migration, Invasion, and Epithelial-Mesenchymal Transition in Lung Adenocarcinoma. FRONT BIOSCI-LANDMRK. 2024 Aug;29(9):314} {WB} {Human}
技术资料暂无技术资料 索取技术资料
文献支持
SGOL2 Rabbit pAb(bs-24137R)-50ul/100ul/200ul
￥1180 - 2800
