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- bs-23110R
- 2025年10月24日
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- 规格：
50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-23110R |
| 英文名称 | RORC Rabbit pAb |
| 中文名称 | 维甲酸相关孤儿受体γ抗体 |
| 英文别名 | RORG_HUMAN; Nuclear receptor ROR-gamma; ROR gamma; NR1F3; RZRG; TOR; IMD42; RZR-GAMMA; Nuclear receptor RZR-gamma; Nuclear receptor subfamily 1 group F member 3; RAR-related orphan receptor C; Retinoid-related orphan receptor-gamma; ROR gamma T [Mus musculus]; nuclear receptor ROR-gamma isoform 2; RORgT; |
| 产品应用 | WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, ICC/IF=1:100-500, IF=1:100-500, Flow-Cyt=1ug/test Not yet tested in other applications. |
| 交叉反应 | Mouse, Rat (Human, Chicken, Dog, Pig, Cow, Horse, Rabbit) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from mouse RORC |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 54 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > Nuclear Receptors > Corticoid Epigenetics and Nuclear Signaling > Transcription > Transcription Factors Signal Transduction > Growth Factors/Hormones > Hormones |
| 亚细胞定位 | Nucleus (Probable). |
| 组织特异性 | Isoform 1: widely expressed in many tissues, including liver and adipose, and highly expressed in skeletal muscle. Isoform 2: Primarily expressed in immature thymocytes. |
| 相似性 | Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| 功能 | Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T helper cells into Th17 cells. Regulate the expression of several components of the circadian clock. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {ICC/IF} | {1:100-500} |
| {IF} | {1:100-500} |
| {Flow-Cyt} | {1ug/test} |
Liver (Mouse) Lysate at 40 ug
Primary: Anti-ROR gamma T (bs-23110R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 54 kD
Observed band size: 54 kD
Lane1: Mouse Muscle Lysates
Lane2: Rat Muscle Lysates
Primary: Anti-ROR Gamma (bs-23110R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 57 kD
Observed band size: 50 kD
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文献和实验[IF={{ 8.786 }}] {Mengyuan Zhu. et al. Insulin-binding protein-5 down-regulates the balance of Th17/Treg.. FRONT IMMUNOL. 2022 Nov;13:1019248-1019248} {IHC} {Mouse}
[IF={{ 6.656 }}] {Yuhan Wu. et al. DiHuangYin decoction protects dopaminergic neurons in a Parkinson's disease model by alleviating peripheral inflammation. PHYTOMEDICINE. 2022 Oct;105:154357} {IF,WB} {Mouse}
[IF={{ 6.1 }}] {Tao Li. et al. Modulatory effect of the fermented Polygonatum cyrtonema Hua on the immune homeostasis and gut integrity in a dextran-sulfate-sodium (DSS)-induced colitis model. FOOD FUNCT. 2024 Feb;:} {IF} {Mouse}
[IF={{ 5.6 }}] {Bing-Bing Cheng. et al. Beneficial effects of Hawthorn extract on metabolic hypertensive rats by regulating Treg/Th17 immune balance. J FUNCT FOODS. 2023 Sep;108:105750} {IHC} {Rat}
[IF={{ 5.4 }}] {Xin Ma. et al. Calycosin enhances treg differentiation for alleviating skin inflammation in atopic dermatitis. J ETHNOPHARMACOL. 2024 Feb;:117883} {IHC} {Mouse}
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