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MMP7 Rabbit pAb(bs-0423R)-50ul

/100ul/200ul

价格￥1180 - 2800

品牌Bioss
货号bs-0423R
更新日期2025年10月16日

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应用范围：
产品信息以Bioss网站为准
规格：
50ul/100ul/200ul

规格：	50ul	产品价格：	￥1180.0
规格：	100ul	产品价格：	￥1980.0
规格：	200ul	产品价格：	￥2800.0

产品编号	bs-0423R
英文名称	MMP7 Rabbit pAb
中文名称	基质金属蛋白酶-7抗体
英文别名	Matrilysin; Matrilysin uterine; Matrin; Matrix Metalloproteinase 7; MMP-7; MMP 7; MMP7; MPSL1; PUMP 1; Pump 1 protease; PUMP1; Uterine Matrilysin; Uterine metalloproteinase; MMP7_HUMAN.
产品应用	WB=1:500-2000, IHC-P=1:50-200, IHC-F=1:50-200, IF=1:50-200, ELISA=1:2000-10000 Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
交叉反应	Human, Mouse (Rat, Monkey)
抗体来源	Rabbit
免疫原	KLH conjugated synthetic peptide derived from human MMP7
亚型	IgG
性状	Liquid
纯化方法	affinity purified by Protein A
克隆类型	Polyclonal
理论分子量	30 kDa
浓度	1mg/ml
储存液	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域	Cancer > Invasion/microenvironment > Angiogenesis > ECM enzymes > MMPs Cancer > Invasion/microenvironment > ECM > Extracellular matrix > MMPs Cancer > Tumor biomarkers > Enzymes > MMPs Cardiovascular > Angiogenesis > Adhesion / ECM > Matrix Metalloproteinases > MMP Cell Biology > Proteolysis / Ubiquitin > Proteolytic enzymes > Metalloprotease > MMPs Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > ECM Enzymes > MMP
亚细胞定位	Secreted, extracellular space, extracellular matrix (Probable).
相似性	Belongs to the peptidase M10A family.
功能	Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.
保存条件	Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料	Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]

应用	推荐稀释比例
{WB}	{1:500-2000}
{IHC-P}	{1:50-200}
{IHC-F}	{1:50-200}
{IF}	{1:50-200}
{ELISA}	{1:2000-10000}

25 ug total protein per lane of various lysates (see on figure) probed with MMP7 polyclonal antibody, unconjugated (bs-0423R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.

P‌‌araformaldehyde-fixed, paraffin embedded Human Prostate; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with MMP7 Polyclonal Antibody, Unconjugated (bs-0423R) at 1:200 overnight at 4°C, followed by conjugation to the SP Kit (Rabbit, SP-0023) and DAB (C-0010) staining.

P‌‌araformaldehyde-fixed, paraffin embedded Human Endometrium; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with MMP7 Polyclonal Antibody, Unconjugated (bs-0423R) at 1:200 overnight at 4°C, followed by conjugation to the SP Kit (Rabbit, SP-0023) and DAB (C-0010) staining.

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文献和实验

该产品被引用文献

[IF={{ 9.075 }}] {Li, Jun. et al. Immunoproteasome inhibition prevents progression of castration-resistant prostate cancer. BRIT J CANCER. 2023 Jan;:1-14} {IHC,IF} {Mouse,Human}

[IF={{ 6.832 }}] {Wu, Haibin. et al. Dextran sulfate prevents excess aggregation of human pluripotent stem cells in 3D culture by inhibiting ICAM1 expression coupled with down-regulating E-cadherin through activating the Wnt signaling pathway. STEM CELL RES THER. 2022 Dec;13(1):1-20} {WB} {Human}

[IF={{ 4.848 }}] {Wang Chengqin. et al. Silencing of KIF3B Suppresses Breast Cancer Progression by Regulating EMT and Wnt/β-Catenin Signaling. Front Oncol. 2021 Jan;10:3063} {WB,IHC} {Human}

[IF={{ 4.17 }}] {Madka, Venkateshwar, et al. "TP53 modulating agent, CP-31398 enhances antitumor effects of ODC inhibitor in mouse model of urinary bladder transitional cell carcinoma." American Journal of Cancer Research 5.10 (2015): 3030.} {WB} {="Mouse"}

[IF={{ 4.162 }}] {Wenwen Chen. et al. Identification of Active Compounds and Mechanism of Huangtu Decoction for the Treatment of Ulcerative Colitis by Network Pharmacology Combined with Experimental Verification. Drug Des Dev Ther. 2021; 15: 4125–4140} {IHC} {mouse}

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