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- bs-13115P
- 2025年10月16日
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500ug
| 产品编号 | bs-13115P |
| 英文名称 | ETV6 Antibody Blocking Peptide |
| 中文名称 | 转录因子ETV6封闭多肽 |
| 英文别名 | ETS related protein Tel 1; ETS related protein Tel1; ETS translocation variant 6; Ets variant 6; Ets variant gene 6 (TEL oncogene); Ets variant gene 6; ETS-related protein Tel1; ETV 6; ETV6; ETV6_HUMAN; TEL 1; TEL 1 oncogene; TEL; TEL oncogene; TEL/ABL; TEL1; TEL1 oncogene; Transcription factor ETV 6; Transcription factor ETV6. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Transcription > Cancer susceptibility > Proto-oncogenes Epigenetics and Nuclear Signaling > Transcription > Domain Families > Ets Epigenetics and Nuclear Signaling > Transcription > Other factors Epigenetics and Nuclear Signaling > Transcription > Transcription Factors |
| 亚基 | Can form homodimers or heterodimers with TEL2 or FLI1. Interacts with L3MBTL1 and HDAC9. |
| 亚细胞定位 | Nucleus. |
| 组织特异性 | Ubiquitous. |
| 翻译后修饰 | Phosphorylation of Ser-257 by MAPK14 (p38) inhibits ETV6 transcriptional repression. |
| 相似性 | Belongs to the ETS family. Contains 1 ETS DNA-binding domain. Contains 1 PNT (pointed) domain. |
| 功能 | Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | ETV6 is the prototype member of a family of genes identified on the basis of homology to the v-Ets oncogene isolated from the E26 erythroblastosis virus. Members of the Ets gene family exhibit varied patterns of tissue expression and share a highly conserved carboxy terminal domain containing a sequence related to the SV40 large T antigen nuclear localization signal sequence. This conserved domain is essential for Ets-1 binding to DNA and is likely to be responsible for the DNA binding activity of all members of the Ets gene family. Several of these proteins have been shown to recognize similar motifs in DNA that share a centrally located 5’-GGAA-3’ element. TEL (for translocation, Ets, leukemia), also designated ETV6, is a member of the Ets family that is involved in specific chromosomal translocations in human leukemia and sarcoma. |
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ETV6 Antibody Blocking Peptide(bs-13115P)-500ug
￥880
