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- Bioss
- bs-11330P
- 2025年10月16日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-11330P |
| 英文名称 | SORCS1 Antibody Blocking Peptide |
| 中文名称 | 液泡蛋白分选受体SORCS封闭多肽 |
| 英文别名 | SorCS 1; SORCS; SORCS-1; SORCS receptor 1; Sortilin related VPS10 domain containing receptor 1; VPS10 domain containing receptor SorCS1; VPS10 domain receptor protein SORCS 1; VPS10 domain receptor protein SORCS; VPS10 domain receptor protein SORCS1; VPS10 domain receptor SorCS; FLJ41758; FLJ43475; FLJ44957; hSorCS; OTTHUMP00000058855; SORC1_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Cell Type Marker > Neuron marker > Soma marker Neuroscience > Neurology process > Neurodegenerative disease > Alzheimer's disease > Amyloid Neuroscience > Neurology process > Neurogenesis Signal Transduction > Protein Trafficking > Organelle Proteins |
| 亚细胞定位 | Membrane; Single-pass type I membrane protein. |
| 组织特异性 | Detected in fetal and infant brain and in fetal retina. |
| 翻译后修饰 | O-glycosylated. |
| 相似性 | Belongs to the VPS10-related sortilin family. SORCS subfamily. Contains 5 BNR repeats. Contains 1 PKD domain. |
| 功能 | SorCS1 belongs to the family of VPS10 domain-containing receptors (the name is derived from the yeast vacuolar protein sorting protein-10, which is involved in sorting of carboxy-peptidase Y from the Golgi apparatus to the vacuole). SorCS1 immunoreactivity is widespread in a population of neurons throughout the brain. Two different types of cellular localization were observed. Most SorCS1 immunoreactive neurons exhibit a punctate cytoplasmic staining which extends into the dendrites, whilst occassionally SorCS1 neuronal immunoreactivity is associated with the plasma membrane. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | There are three sorCS genes that have diverse, partially overlapping functions in the central nervous system. In the developing and mature central nervous system, the homologous SorCS1 and SorCS2 genes and the SorCS3 gene are expressed in a combinatorial, non-overlapping pattern. SorCS proteins show homology to the mosaic receptor SorLA and the neurotensin receptor sortilin, based on a common VPS10 domain, which is the hallmark of the SorCS receptor family. SorCS1 is a type 1 receptor containing a VPS10P domain and a leucine-rich domain. Alternative splicing of human SorCS1 results in four isoforms with different cytoplasmic tails and differential expression in tissues. Human SorCS1 is detected in fetal and infant brain and in fetal retina. Alternative splicing of murine SorCS1 also results in four isoforms. Murine isoform 1 is highly expressed in brain and at lower levels in heart, liver and kidney. It is detected in newborn mouse brain and in adult olfactory bulb and cerebral cortex. Murine isoform 2 is highly expressed in liver and at lower levels in heart, brain, kidney and testis. |
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SORCS1 Antibody Blocking Peptide(bs-11330P)-500ug
￥880
