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- bs-1587P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-1587P |
| 英文名称 | F13B Antibody Blocking Peptide |
| 中文名称 | 凝血因子13(纤维蛋白稳定因子)封闭多肽 |
| 英文别名 | coagulation factor XIII; F13A1; TGase; FXIIIA; F13A; Coagulation factor XIII A chain; Coagulation factor XIIIa; Protein-glutamine gamma-glutamyltransferase A chain; Transglutaminase A chain; coagulation factor XIII, A1 polypeptide; coagulation factor XIII A chain-like. |
| 纯化方法 | HPLC |
| 研究领域 | Cardiovascular > Blood > Coagulation > Common Cardiovascular > Blood > Serum Proteins |
| 亚基 | Tetramer of two A chains and two B chains. |
| 亚细胞定位 | Cytoplasm. Secreted. Note=Secreted into the blood plasma. Cytoplasmic in most tissues, but also secreted in the blood plasma. Tissue Specificity : The activation peptide is released by thrombin. |
| 组织特异性 | The activation peptide is released by thrombin. |
| 相似性 | Belongs to the transglutaminase superfamily. Transglutaminase family. |
| 功能 | Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. |
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F13B Antibody Blocking Peptide(bs-1587P)-500ug
￥880
