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| 产品编号 | bs-12053P |
| 英文名称 | 5HT3D Receptor Antibody Blocking Peptide |
| 中文名称 | 5-羟色胺受体3D封闭多肽 |
| 英文别名 | 5 hydroxytryptamine receptor 3D; 5-hydroxytryptamine receptor 3 subunit D; 5HT3D; HTR3D; MGC119636; MGC119637; Serotonin 5-HT-3D receptor; Serotonin receptor 3D; 5HT3D_HUMAN. |
| 纯化方法 | HPLC |
| 亚基 | Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex. |
| 亚细胞定位 | Cell membrane; Multi-pass membrane protein. Note: Presumably retained within the endoplasmic reticulum unless complexed with HTR3A. |
| 组织特异性 | Expressed in liver, as well as fetal and adult colon and kidney. |
| 相似性 | Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3D sub-subfamily. |
| 功能 | This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Serotonin is a monoamine neurotransmitter that is made in serotonergic neurons in the CNS (central nervous system) and is important in the regulation of mood, sleep, vomiting, sexuality and appetite. 5-HT3 (5-hydroxytryptamine-3) receptor is the only ligand-gated ion channel within the family of serotonin receptors. It is composed of five subunits consisting of SR-3A, SR-3B, HTR3C, HTR3D and HTR3E. HTR3D (5-hydroxytryptamine receptor 3D), also known as Serotonin receptor 3D, is a 454 amino acid multi-pass membrane protein that is one components of the pentaheteromeric complex that forms the 5-HT3 receptor. HTR3D must be co-expressed with SR-3A to form a functional 5-HT3 receptor complex on the plasma membrane. Until it is complexed with SR-3A, HTR3D is localized within the endoplasmic reticulum. Expression of HTR3D is restricted to kidney, colon and liver. There are three different isoforms of HTR3D that are expressed as a result of alternative splicing events. |
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文献和实验Characterization of CGRP Receptor Binding
. Poyner, D.R., Andrew, D.P., Brown, D., Bose, C., and Hanley, M.R. 1992. Pharmacological characterization of a receptor for calcitonin gene‐related peptide on rat, L6 myocytes. Br. J. Pharmacol. 105:441‐447
Mapping Protein‐Protein Interactions with Phage‐Displayed Combinatorial Peptide Libraries
., Chang, C.Y., Ballas, L.M., Hamilton, P.T., McDonnell, D.P., and Fowlkes, D.M. 1999. Estrogen receptor (ER) modulators each induce distinct conformational changes in ER alpha and ER beta. Proc. Natl. Acad. Sci. U.S.A. 96:3999‐4004
, 1983 M.Phil. Molecular Biophysics & Biochemistry, Yale University, 1986 Ph.D. Molecular Biophysics & Biochemistry, Yale University, 1991 Bioinformatics, simulations, computational biology, structural biology Dr. Wishart?s formal training
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