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- bs-12689P
- 2025年10月16日
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500ug
| 产品编号 | bs-12689P |
| 英文名称 | PRKCI Antibody Blocking Peptide |
| 中文名称 | 磷酸化蛋白激酶C亚型PKCI封闭多肽 |
| 英文别名 | aPKC lambda/iota; aPKC-lambda/iota; Atypical protein kinase C lambda/iota; Atypical protein kinase C-lambda/iota; DXS1179E; KPCI_HUMAN; MGC26534; nPKC iota; nPKC-iota; nPKCiota; PKC lambda; PKCI; PKCiota; PKClambda; PRKC iota; PRKC lambda/iota; PRKC-lambda/iota; PRKCI; Protein kinase C iota; Protein kinase C iota type. |
| 纯化方法 | HPLC |
| 研究领域 | Signal Transduction > Protein Phosphorylation > Ser / Thr Kinases > PKC Signal Transduction > Protein Trafficking > Vesicle Transport > Regulation |
| 亚细胞定位 | Cytoplasm. Membrane. Endosome. Nucleus. Transported into the endosome through interaction with SQSTM1/p62. After phosphorylation by cSrc, transported into the nucleus through interaction with KPNB1. Colocalizes with CDK7 in the cytoplasm and nucleus. Vesicular tubular clusters. Transported to VTCs through interaction with RAB2A. |
| 组织特异性 | Predominantly expressed in lung and brain, but also expressed at lower levels in many tissues including pancreatic islets. Highly expressed in non-small cell lung cancers. |
| 翻译后修饰 | On neuronal growth factor (NGF) stimulation, phosphorylated by Src on Tyr-265, Tyr-280 and Tyr-334. Phosphorylation on Tyr-265 facilitates binding to KPNB1/importin-beta regulating entry of PRKCI into the nucleus. Phosphorylation on Tyr-334 is important for NF-kappa-B stimulation. |
| 相似性 | Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. Contains 1 AGC-kinase C-terminal domain. Contains 1 OPR domain. Contains 1 phorbol-ester/DAG-type zinc finger. Contains 1 protein kinase domain. |
| 功能 | Calcium-independent, phospholipid-dependent, serine- and threonine-specific kinase. May play a role in the secretory response to nutrients. Involved in cell polarization processes and the formation of epithelial tight junctions. Implicated in the activation of several signaling pathways including Ras, c-Src and NF-kappa-B pathways. Functions in both pro- and anti-apoptotic pathways. Functions in the RAC1/ERK signaling required for transformed growth. Plays a role in microtubule dynamics through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008] |
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PRKCI Antibody Blocking Peptide(bs-12689P)-500ug
￥880
