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- Bioss
- bs-16384P
- 2025年10月16日
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500ug
| 产品编号 | bs-16384P |
| 英文名称 | phospho-Hck (Tyr411) Antibody Blocking Peptide |
| 中文名称 | 磷酸化造血细胞激酶封闭多肽 |
| 英文别名 | Hck (phospho Y411); Hck (phospho Tyr411); Bmk; Hck 1; Hemopoietic cell kinase; Hemopoietic cell kinase isoform p59 Hck; JTK 9; JTK9; MGC 18625; MGC18625; p59 HCK/p60 HCK; p59HCK/p60HCK; Tyrosine protein kinase HCK; HCK_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Immunology > Immune System Diseases > Antiviral Signaling Signal Transduction > Protein Phosphorylation > Tyrosine Kinases > Src Family |
| 亚基 | Interacts (via SH2 domain) with FLT3 (tyrosine phosphorylated). Interacts with VAV1, WAS and RAPGEF1. Interacts (via SH3 domain) with HIV-1 Nef and Vif. This interaction stimulates its tyrosine-kinase activity. Interacts (via SH3 domain) with HEV ORF3 protein. Interacts with ARRB1 and ARRB2. Interacts with ADAM15. Interacts with FASLG. Interacts with CBL. Interacts with FCGR1A; the interaction may be indirect. Interacts with IL6ST. Interacts (via SH3 domain) with ELMO1. Interacts (via SH3 domain) with TP73. Interacts with YAP1. Interacts with ABL1 and ITGB1, and thereby recruits ABL1 to activated ITGB1. |
| 亚细胞定位 | Membrane. Cytoplasm. At least half of this isoform is found in the cytoplasm, some of this fraction is myristoylated and Membrane. Membrane > caveola. 20% of this isoform is associated with caveolae, this association depends on palmitoylation of cyteine at position 3. |
| 组织特异性 | Detected in monocytes and neutrophils (at protein level). Expressed predominantly in cells of the myeloid and B-lymphoid lineages. Highly expressed in granulocytes. Detected in tonsil. |
| 相似性 | Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. Contains 1 protein kinase domain. Contains 1 SH2 domain. Contains 1 SH3 domain. |
| 功能 | May serve as part of a signaling pathway coupling the Fc receptor to the activation of the respiratory burst. May also contribute to neutrophil migration and may regulate the degranulation process of neutrophils. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | HCK is a tyrosine kinase that is predominantly expressed in hemopoietic cell types. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. |
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phospho-Hck (Tyr411) Antibody Blocking Peptide(bs-16384P)-500ug
￥1080
