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- 2025年10月16日
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500ug
| 产品编号 | bs-20428P |
| 英文名称 | VWF (Von Willebrand Factor) Antibody Blocking Peptide |
| 中文名称 | 血管假性血友病因子/血管性血友病因子封闭多肽 |
| 英文别名 | Von Willebrand Factor; Coagulation factor VIII; F8VWF; Factor VIII related antigen; von Willebrand antigen 2; Von Willebrand antigen II; Von Willebrand disease; VWD; VWF; VWF_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Invasion/microenvironment > Angiogenesis > Angiogenic growth factors Cardiovascular > Angiogenesis > Endothelial Cell Markers Cardiovascular > Blood > Coagulation > Extrinsic Cardiovascular > Blood > Coagulation > Regulatory Cardiovascular > Blood > Platelets Cardiovascular > Blood > Serum Proteins Stem Cells > Endothelial Progenitors > Endothelial Markers |
| 亚基 | Multimeric. Interacts with F8. |
| 亚细胞定位 | Secreted. Secreted, extracellular space, extracellular matrix. Note=Localized to storage granules. |
| 组织特异性 | Plasma. |
| 翻译后修饰 | All cysteine residues are involved in intrachain or interchain disulfide bonds. N- and O-glycosylated. |
| 相似性 | Contains 1 CTCK (C-terminal cystine knot-like) domain. Contains 4 TIL (trypsin inhibitory-like) domains. Contains 3 VWFA domains. |
| 功能 | Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Von Willebrand Factor (VWF) was previously known as Factor VIII related antigen. VWF is synthesized exclusively by endothelial cells and megakaryocytes, and stored in the intracellular granules or constitutively secreted into plasma. This glycoprotein functions as both an antihemophilic factor carrier and a platelet vessel wall mediator in the blood coagulation system. Important in the maintenance of homeostasis, it participates in platelet vessel wall interactions by forming a noncovalent complex with coagulation factor VIII at the site of vascular injury. The Von Willebrand factor has functional binding domains to platelet glycoprotein Ib, glycoprotein IIb/IIIa, collagen and heparin. Mutations in this gene or deficiencies in this protein result in Von Willebrand's disease. VWD is characterized by frequent bleeding (gingival, minor skin quantitative lacerations, menorrhagia, etc.). |
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文献和实验[IF={{ 4.8 }}] {Ting Shu. et al. Sensitive electrochemical detection of von Willebrand factor using an immunosensor comprising 7,7,8,8-tetracyanoquinodimethane and nickel-based metal–organic framework. MICROCHEM J. 2023 Sep;:109351} {Other} {}
or from the literature are missing. In this article, processing parameters for DNA, peptide, antibody, and carbohydrate microarrays are outlined. The applicability of the model experiments is demonstrated and described in detail on the example of short oligonucleotides.
【翻译】Development trends for monoclonal antibody cancer therapeutics
, both of which could inhibit proliferation of targeted cells and prevent the advance of cancerous disease. Three approved unmodified mAbs (all IgG1) are believed to function primarily by blocking epidermal growth factor receptor (EGFR, also known as HER1) — cetuximab (Erbitux
effector cells, radionuclides, drugs, and toxins, or by simultaneously blocking two relevant tumor targets, that is, growth factor receptors, thus neutralizing multiple receptor activation and downstream signal transduction pathways. A major obstacle
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