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- Bioss
- bs-14689R-PE
- 2025年10月15日
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100ul
| 产品编号 | bs-14689R-PE |
| 英文名称 | FAM105B Rabbit pAb, PE conjugated |
| 中文名称 | PE标记的FAM105B蛋白抗体 |
| 英文别名 | OTUL_HUMAN; Fam105b; Family with sequence similarity 105, member B; FLJ34884; OTULIN; Protein FAM105B. |
| 产品应用 | IF=1:50-200, ICC/IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human FAM105B |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Epigenetics and Nuclear Signaling > Ubiquitin & Ubiquitin Like Modifiers > Deubiquitination Signal Transduction > Signaling Pathway > Nuclear Signaling > NFkB Pathway |
| 亚基 | Interacts with RNF31; the interaction is direct. |
| 亚细胞定位 | Cytoplasm. |
| 翻译后修饰 | Ubiquitinated. Acetylated. Phosphorylated. |
| 相似性 | Belongs to the FAM105 family. |
| 功能 | Deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response. Associates with the LUBAC complex via direct interaction with RNF31 and counteracts its action by cleaving linear polyubiquitin chains to substrates. Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex. Acts as a negative regulator of NF-kappa-B by counteracting activity of the LUBAC complex. Plays a key role in innate immune response: required to restrict linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation, probably to limit NOD2-dependent proinflammatory signaling. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | With 181 million base pairs encoding around 1,000 genes, chromosome 5 is about 6% of human genomic DNA. It is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5 associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome. Deletion of 5q or chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome. The FAM105B gene product has been provisionally designated FAM105B pending further characterization. |
| 应用 | 推荐稀释比例 |
| {IF} | {1:50-200} |
| {ICC/IF} | {1:100-500} |
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FAM105B Rabbit pAb, PE conjugated(bs-14689R-PE)-100ul
￥2980
