FAN1 Rabbit pAb, HRP conjugated(bs-13137R-HRP)-100ul

FAN1 Rabbit pAb, HRP conjugate

d(bs-13137R-HRP)-100ul
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  • ￥2980
  • Bioss已认证
  • bs-13137R-HRP
  • 2025年09月30日
  • 产品信息以Bioss网站为准
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北京博奥森生物技术有限公司
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    • 应用范围：

      产品信息以Bioss网站为准

    • 规格：

      100ul

    产品编号bs-13137R-HRP
    英文名称FAN1 Rabbit pAb, HRP conjugated
    中文名称HRP标记的范可尼综合征相关蛋白FAN1抗体
    英文别名6030441H18Rik; Coiled coil domain containing protein MTMR15; DKFZp451H236; DKFZp686K16147; FAN1; FAN1_HUMAN; FANCD2/FANCI associated nuclease 1; FANCD2/FANCI-associated nuclease 1; Fanconi associated nuclease 1; Fanconi-associated nuclease 1; KIAA1018; MTMR 15; MTMR15; Myotubularin related protein 15; Myotubularin-related protein 15.
    产品应用IHC-P=1:100-500, IHC-F=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human FAN1
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Epigenetics and Nuclear Signaling > DNA / RNA > DNA Damage & Repair > Fanconi's Anemia

    亚基Interacts with FANCD2 (when monoubiquitinated). Interacts with FANCI, MLH1, MLH3 and PMS2.
    亚细胞定位Nucleus. Localizes at sites of DNA damage following recruitment by monoubiquitinated FANCD2.
    相似性Belongs to the FAN1 family.
    _x000D_ Contains 1 UBZ-type zinc finger.
    _x000D_ Contains 1 VRR-NUC domain.
    功能Nuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrand cross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, possibly in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonuclease activity toward 5'-flaps and 5'-exonuclease activity: may act in concert with the 3'-flap-specific enzymes to unhook the ICL by cleaving the lagging-strand template.
    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Nuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrand cross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, possibly in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonuclease activity toward 5'-flaps and 5'-exonuclease activity: may act in concert with the 3'-flap-specific enzymes to unhook the ICL by cleaving the lagging-strand template.

     

    应用推荐稀释比例
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}

     

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