TFEB Rabbit pAb, FITC conjugated(bs-5137R-FITC)-100ul产品图

TFEB Rabbit pAb, FITC conjugat

ed(bs-5137R-FITC)-100ul
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  • bs-5137R-FITC
  • 2025年10月15日
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      100ul

    产品编号bs-5137R-FITC
    英文名称TFEB Rabbit pAb, FITC conjugated
    中文名称FITC标记的T淋巴细胞转录调节因子TFEB抗体
    英文别名alpha TFEB; alphaTFEB; bHLHe35; T cell transcription factor EB; T-cell transcription factor EB; TCFEB; Transcription factor EB; TFEB_HUMAN.
    产品应用IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human TFEB
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Epigenetics and Nuclear Signaling > Transcription > Domain Families > HLH / Leucine Zipper

    Epigenetics and Nuclear Signaling > Transcription > Domain Families > HLH / Leucine Zipper > HLH / Leucine Zipper

    Epigenetics and Nuclear Signaling > Transcription > Transcription Factors

    Tags & Cell Markers > Cell Type Markers > Tumor Associated

    亚基Homodimer and heterodimer; with TFE3 or MITF.
    亚细胞定位Cytoplasm. Nucleus. Note=Mainly present in the cytoplasm. Under aberrant lysosomal storage conditions, it translocates from the cytoplasm to the nucleus.
    翻译后修饰Sumoylated; does not affect dimerization with MITF.
    相似性Belongs to the MiT/TFE family.
    Contains 1 basic helix-loop-helix (bHLH) domain.
    功能Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta.
    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Transcription factors of the basic helix-loop-helix zipper (bHLH-ZIP) family contain a basic domain, used for DNA binding, and HLH and ZIP domains, both used for oligomerization. TFEB was isolated from a human B-cell cDNA library using a binding sequence from the adenovirus major late promoter. This transcription factor probably binds to the USF/MLTF site and probably recognizes E-box sequences in the heavy-chain immunoglobulin enhancer.

     

    应用推荐稀释比例
    {IF}{1:100-500}

     

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