GABRA1/GABA A Receptor alpha 1 Rabbit pAb(bs-1232R)-50ul/100ul/200ul
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GABRA1/GABA A Receptor alpha 1

Rabbit pAb(bs-1232R)-50ul/100ul/200ul
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  • ￥1180 - 2800
  • Bioss已认证
  • bs-1232R
  • 2025年10月17日
  • 产品信息以Bioss网站为准
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      50ul/100ul/200ul

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    规格：200ul产品价格：￥2800.0
    产品编号bs-1232R
    英文名称GABRA1/GABA A Receptor alpha 1 Rabbit pAb
    中文名称G1氨基丁酸A型受体α1抗体
    英文别名ECA4; EJM; EJM5; Gaba receptor alpha 1 polypeptide; GABA(A) receptor; GABA(A) receptor subunit alpha 1; GABA(A) receptor subunit alpha-1; GABA(A) receptor, alpha 1; GABRA 1; GABRA1; gamma aminobutyric acid(GABA) A receptor alpha 1; gamma aminobutyric acid A receptor alpha 1; gamma aminobutyric acid receptor subunit alpha 1; gamma-aminobutyric acid receptor subunit alpha-1; GBRA1_HUMAN.
    产品应用WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Mouse, Rat (Human, Chicken, Dog, Cow, Horse)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human GABRA1
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量52 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    亚基Binds UBQLN1. Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with TRAK1.
    亚细胞定位Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
    组织特异性Highly expressed in brain and weakly in heart, small intestine and uterus. Isoform 1A is mostly expressed in granular cell and molecular layer. Isoform 1B is mostly expressed in Purkinje cells. Isoform 1E is predominantly expressed in peripheral tissues as kidney, lung, trachea, colon, small intestine, stomach, bone marrow, thymus and mammary gland.
    相似性Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily.
    GABRA1 sub-subfamily.
    功能GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (g-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA R alpha 1-6, GABAA R beta 1-3, GABAA R©1-3, GABAA R∂, GABAA R gamma, GABAA R delta 1 and GABAA R delta 2. The GABAB family is composed of GABAB R1 alpha and GABAB R1 beta. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2 and -3). The GABA transporters function to terminate GABA action.

     

    应用推荐稀释比例
    {WB}{1:500-2000}
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}
    {IF}{1:100-500}

     

    GABRA1/GABA A Receptor alpha 1
    Sample: Brain (Mouse) Lysate at 40 ug
    Primary: Anti-GABA A Receptor (bs-1232R) at 1/300 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/10000 dilution
    Predicted band size: 52 kD
    Observed band size: 52 kD
    GABRA1/GABA A Receptor alpha 1
    P‌‌araformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (GABRA1 GABA A Receptor alpha 1) Polyclonal Antibody, Unconjugated (bs-1232R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
    GABRA1/GABA A Receptor alpha 1
    Sample:
    Cerebrum (Mouse) Lysate at 40 ug
    Cerebellum (Rat) Lysate at 40 ug
    Primary: Anti-GABRA1/GABA A Receptor alpha 1 (bs-1232R) at 1/1000 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 52 kD
    Observed band size: 52 kD
    GABRA1/GABA A Receptor alpha 1
    P‌‌araformaldehyde-fixed, paraffin embedded (mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (GABRA1 GABA A Receptor alpha 1) Polyclonal Antibody, Unconjugated (bs-1232R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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    图标文献和实验
    该产品被引用文献

    [IF={{ 6.1 }}] {Sharma Bhupender. et al. MicroRNA-502-3p regulates GABAergic synapse function in hippocampal neurons. NEURAL REGEN RES. 2024 Mar;:10.4103/NRR.NRR} {WB} {Mouse}

    [IF={{ 6.083 }}] {Kumar, Subodh. et al. Synaptosome microRNAs regulate synapse functions in Alzheimer’s disease. NPJ GENOM MED. 2022 Aug;7(1):1-15} {WB} {Human}

    [IF={{ 3.3 }}] {Fengjin He. et al. Therapeutic potential of Rosa roxburghii folium extract in insomnia treatment: a comprehensive evaluation of behavioral and neurochemical effects in a PCPA-induced mouse model. J SCI FOOD AGR. 2024 Sep;:} {WB} {Mouse}

    [IF={{ 2 }}] {H Liu. et al.Etomidate ameliorates Alzheimer-like neuropathology and cognitive impairment in APP/PS1 mice..JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY.2025 Feb;76(1).} {Western blot} {Mouse}

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    GABRA1/GABA A Receptor alpha 1 Rabbit pAb(bs-1232R)-50ul/100ul/200ul
    ￥1180 - 2800