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| 规格： | 10ug | 产品价格： | ￥750.0 |
|---|---|---|---|
| 规格： | 50ug | 产品价格： | ￥2250.0 |
| 规格： | 500ug | 产品价格： | ￥9000.0 |
| 产品编号 | bs-48057P |
| 英文名称 | Recombinant human IL-21 protein (Active, CHO) |
| 中文名称 | 重组人白细胞介素21 |
| 英文别名 | Interleukin-21; Za11; IL21; |
| 性状 | Lyophilized |
| 纯化方法 | AC |
| 理论分子量 | 15.9 |
| 储存液 | PBS, 5% Mannitol and 0.01% Tween 80 (pH=7.4) |
| 亚细胞定位 | Secreted. |
| 组织特异性 | Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. |
| 相似性 | Belongs to the IL-15/IL-21 family. |
| 功能 | Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. |
| 保存条件 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 36 months at -20℃ to -80℃ in lyophilized state. 6 months at -20℃ to -80℃ under sterile conditions after reconstitution. 7-10 days at 2℃ to 8℃ under sterile conditions after reconstitution. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | IL-21 is a typical family I cytokine with broad pleiotropic actions and is primarily produced by T follicular helper cells, Th17, and natural killer T cells in response to antigenic stimulation. Il-21 generally enhances antigen-specific responses of immune cells. It controls the activation, proliferation, differentiation, cytotoxicity, and survival of various target immune cells. Additionally, IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 elicits its effect through binding to IL-21R, which also contains the gamma chain found in other cytokine receptors such as IL-2, IL-4, IL-7, IL-9 and IL-15. IL-21/IL-21R interaction triggers a cascade of events, which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3. Recombinant Human IL-21 is a 15.4 kDa protein consisting of 132 amino acid residues. |
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