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- bs-13456P
- 2026年10月10日
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- 文献和实验
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500ug
| 产品编号 | bs-13456P |
| 英文名称 | GMEB2 Antibody Blocking Peptide |
| 中文名称 | 糖皮质激素调节元件结合蛋白2封闭多肽 |
| 英文别名 | GMEB2; DNA binding protein p79PIF; DNA-binding protein p79PIF; Glucocorticoid modulatory element binding protein 2; Glucocorticoid modulatory element-binding protein 2; GMEB 2; GMEB-2; Gmeb2; GMEB2_HUMAN; KIAA1269; P79PIF; Parvovirus initiation factor p79; PIF p79; PIF79; RP4 663D7.1. |
| 纯化方法 | HPLC |
| 亚基 | Homodimer, and heterodimer of GMEB1 and GMEB2. GMEB1 and GMEB2 form the parvovirus initiator complex (PIF). Interacts with the glucocorticoid receptor (NR3C1). May interact with CREB-binding protein (CBP). |
| 亚细胞定位 | Nucleus. Cytoplasm. May be also cytoplasmic. |
| 组织特异性 | Expressed in peripheral blood lymphocytes and fetal liver. Expressed preferentially in reproductive and/or developmentally important cells, such as testis, placenta, bone marrow and fetal tissues. |
| 相似性 | Contains 1 SAND domain. |
| 功能 | Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | GMEB-2 is a DNA-binding protein that plays a crucial role modulating transcription upon activation by steroid hormones. GMEB-2 is ubiquitously expressed with preferential expression in developmentally important tissues, such as testis, bone marrow, placenta and fetal tissues. It localizes to the nucleus and cytoplasm and contains a SAND domain near its N-terminus and a C-terminal coiled coil structure. GMEB-2 functions as a homodimer or as a heterodimer with GMEB-1. The formed complex specifically binds to glucocorticoid modulatory elements (GME) in the promoter region of target genes and recruits the histone acetylase CREB binding protein (CBP) during glucocorticoid signaling. This acts to increase sensitivity to low concentrations of glucocorticoids. In addition, GMEB-2 functions as an auxiliary factor required for parvovirus replication. |
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文献和实验相关实验
0.3% hydrogen peroxide (prepare immediately before use) Blocking buffer (see recipe ) HCV‐specific primary antibody (Ab), e.g
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GMEB2 | PIF p79 Ab Blocking Peptide(bs-13456P)-500ug
￥880
