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- bs-12120P
- 2026年10月10日
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500ug
| 产品编号 | bs-12120P |
| 英文名称 | SCG2 Antibody Blocking Peptide |
| 中文名称 | 嗜铬粒蛋白C封闭多肽 |
| 英文别名 | CHGC; Chromogranin-C; MEN1; SCG2; SCG2_HUMAN; Secretogranin II; Secretogranin-2; Secretoneurin; Secretoneurin included; SgII; SN. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Neurotransmission > Secretory Vesicles > Granins Neuroscience > Neurotransmitter > Neuropeptides > Hormones |
| 亚细胞定位 | Secreted. Neuroendocrine and endocrine secretory granules. |
| 组织特异性 | Belongs to the chromogranin/secretogranin protein family. |
| 相似性 | Belongs to the chromogranin/secretogranin protein family. |
| 功能 | Secretogranin-2 is a neuroendocrine secretory granule protein, which is the precursor for biologically active peptides. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Chromogranins (secretogranins) are acidic glycoproteins that localize within secretory granules of endocrine, neuroendocrine and neuronal tissue. Family members include chromogranin A (Chr-A); chromogranin B (Chr-B), also known as secretogranin I; chromogranin C (also known as secretogranin II or Sg II); and secretogranin III (Sg III or SCG3). High levels of Chr-A expression are characteristic of neuroendocrine tumors. Pancreastatin is a peptide derived from Chr-A which inhibits insulin secretion, exocrine pancreatic secretion and gastric acid secretion. Pancreastatin exists as two forms; the major form is expressed in stomach and colon extracts. In neuroendocrine cells the level Sg II has been shown to increase four-fold in response to histamine, while levels of Chr-A and Chr-B showed little or no increase. Sg III is an acidic secretory protein expressed in neuronal and endocrine cells. In the anterior lobe of the rat pituitary gland, Sg III is present in mammotropes and thyrotropes, moderately in gonadotropes and corticotropes, though not in somatotropes. Sg III and carboxypeptidase E (CPE) bind specifically to cholesterol-rich secretory granule (SG) membranes. |
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文献和实验0.3% hydrogen peroxide (prepare immediately before use) Blocking buffer (see recipe ) HCV‐specific primary antibody (Ab), e.g
Dual-Color ELISPOT Assay for the Simultaneous Detection of IL-2 and/or IFN- Secreting T Cells
, activate AEC buffer using H2 O2 (see Step 25). Anti-CD3 monoclonal antibody (mAb) (Fisher Scientific) Blocking buffer for ELISPOT assay CEF peptide pool (available from the NIH AIDS Research and Reagent Program and other commercial
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