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- Bioss
- bs-12114P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-12114P |
| 英文名称 | CHRND Antibody Blocking Peptide |
| 中文名称 | ***型乙酰胆碱受体δ/AChRδ封闭多肽 |
| 英文别名 | Acetylcholine receptor delta subunit; Acetylcholine receptor subunit delta; ACHD_HUMAN; ACHRD; Cholinergic receptor, nicotinic, delta polypeptide; CHRND; CMS2A; FCCMS; Nicotinic acetylcholine receptor delta polypeptide precursor; SCCMS. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Neurotransmission > Receptors / Channels > Ligand-Gated Ion Channels > nAch Receptors |
| 亚基 | Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains. |
| 亚细胞定位 | Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. |
| 相似性 | Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
Delta/CHRND sub-subfamily. |
| 功能 | After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Members of the ligand-gated ion channel receptor family are characterized by their fast transmitting response to neurotransmitters. Two important members of this family are the nicotinic acetylcholine and glutamate receptors, both of which are composed of five homologous subunits forming a transmembrane aqueous pore. These transmembrane receptors change conformation in response to their cognate neurotransmitter. Nicotinic acetylcholine receptors (AChRs) are found at the postsynaptic membrane of the neuromuscular junction and bind acetylcholine molecules, allowing ions to move through the pore. Glutamate receptors are found in the postsynaptic membrane of cells in the central nervous system. The activity that is generated at the synapse by the binding of acetylcholine is terminated by acetylcholinesterase, an enzyme that rapidly hydrolyzes acetylcholine. AChR delta, also known as CMS2A, FCCMS, SCCMS or CHRND, is a 517 amino acid multi-pass membrane protein that is associated with lethal type multiple pterygium syndrome, congenital myasthenic syndrome slow-channel type (SCCMS) and congenital myasthenic syndrome fast-channel type (FCCMS). |
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CHRND Antibody Blocking Peptide(bs-12114P)-500ug
￥880
