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| 产品编号 | bs-41609P |
| 英文名称 | Human Prostate Specific Antigen protein |
| 中文名称 | 人前列腺特异性抗原（天然蛋白） |
| 英文别名 | PSA; Native Human Prostate Specific Antigen protein; Prostate Specific Antigen, Native; |
| 性状 | Lyophilized |
| 理论分子量 | 34 |
| 研究领域 | Cancer > Tumor biomarkers > Tumor antigens Cancer > Tumor immunology > Tumor-associated antigens Neuroscience > Cell Adhesion Proteins > Proteases Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > ECM Enzymes > Kallikreins Tags & Cell Markers > Cell Type Markers > Tumor Associated |
| 亚基 | Forms heterodimer with SERPINA5. |
| 亚细胞定位 | Secreted. |
| 组织特异性 | Prostate. |
| 翻译后修饰 | Belongs to the peptidase S1 family. Kallikrein subfamily. _x000D_ Contains 1 peptidase S1 domain. |
| 相似性 | Belongs to the peptidase S1 family. Kallikrein subfamily. Contains 1 peptidase S1 domain. |
| 功能 | Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum. |
| 保存条件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. |
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文献和实验[IF=8.008] Li Fu. et al. A General Route for Chemiluminescence of n-Type Au Nanocrystals. ANAL CHEM. 2022;94(24):8811–8817 Other
[IF=8.008] Yuqi Xu. et al. Surface Defect-Involved and Single-Color Electrochemiluminescence of Gold Nanoclusters for Immunoassay. ANAL CHEM. 2022;94(35):12070–12077 Other Other
[IF=8.008] Li Fu. et al. Coreactant-free and Near-Infrared Electrochemiluminescence Immunoassay with n-Type Au Nanocrystals as Luminophores. ANAL CHEM. 2022;94(34):11934–11939 Other Other
[IF=8.008] Xuwen Gao. et al. Spectrum-Resolved Electrochemiluminescence to Multiplex the Immunoassay and DNA Probe Assay. ANAL CHEM. 2022;XXXX(XXX):XXX-XXX Other
[IF=8.008] Xuwen Gao. et al. Luminophore-Surface-Engineering-Enabled Low-Triggering-Potential and Coreactant-Free Electrochemiluminescence for Protein Determination. ANAL CHEM. 2023;95(17):6948–6954 Other
Evaluation of Peptides as Protease Inhibitors and Stimulators
. We present here detailed protocols for basic evaluation of the effects of peptides on the activity of proteases, using kallikrein-related peptidases KLK2 and KLK3 (also known as hK2 and PSA), and trypsin as examples. KLK2 and KLK3 are major prostatic
Nucleic Acid Programmable Protein Arrays: Versatile Tools for Array‐Based Functional Protein Studies
density protein microarrays. J. Proteome Res. 7:2059‐2068. Montor, W.R., Huang, J., Hu, Y., Hainsworth, E., Lynch, S., Kronish, J.W., Ordonez, C.L., Logvinenko, T., Lory, S
前髓细胞性白血病，是急性髓样白轿病的一种独特的亚型（FABM3）,具有t[15；17][q22；q12-21]易位的特征，使染色体15上被称为PML的转录因子与维甲类细胞核受体α[RARα]融合，导致在APL细胞中表达PML/RARα融合性蛋白。 Adaptor protein 适配子（衔接子）蛋白，一种不含央在酶活性的蛋白质，但含有多种蛋白-蛋白相互作用域，如SH2/SH3域作为活化的细胞表面受体与各种细胞内信号转导蛋白之间的桥梁，把细胞膜活化复合物中的蛋白质连在一起。
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