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- Bioss
- bs-2457P
- 2025年10月16日
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500ug
| 产品编号 | bs-2457P |
| 英文名称 | TNFRSF14 Antibody Blocking Peptide |
| 中文名称 | 肿瘤坏死因子受体超家族成员14封闭多肽 |
| 英文别名 | HVEM; Tumor necrosis factor receptor superfamily member 14; HVEML; ATAR; CD258; CD258 antigen; CD40 like protein precursor; Herpesvirus entry mediator A; Herpesvirus entry mediator; Herpesvirus entry mediator ligand; HVEA; HVEM L; HVEML; LIGHT; LIGHTR; TNFSF 14; TR2; Tumor necrosis factor receptor like gene2; TNR14_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Growth factors > TNF Immunology > Immune System Diseases > Antiviral Signaling Immunology > Innate Immunity > Cytokines > TNF Superfamily Signal Transduction > Growth Factors/Hormones > TNF |
| 亚基 | Interacts with TRAF2, TRAF3 and TRAF5. Interacts with herpes simplex virus 1 (HHV-1) and herpes simplex virus 1 (HHV-2) envelope glycoprotein D; functions as an entry receptor for these viruses. |
| 亚细胞定位 | Membrane; Single-pass type I membrane protein |
| 组织特异性 | Widely expressed, with the highest expression in lung, spleen and thymus. |
| 翻译后修饰 | N-glycosylated. |
| 相似性 | Contains 3 TNFR-Cys repeats. |
| 功能 | Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | TNFRSF14 is a type I membrane protein belonging to the TNF receptor superfamily. This receptor mediates herpes virus entry into cells during infection. TNFRSF14 is able to inhibit the proliferation, activation, and cytokine production of T cells. It has an extracellular domain containing several cysteine-rich repeats and a short cytoplasmic region containing a TRAF (TNF receptor-associated factor) interaction domain. The extracellular domain of TNFRSF14 interacts with the herpes simplex virus envelope glycoprotein D. TNFRSF14 binds two cellular ligands: lymphotoxin alpha and LIGHT. LIGHT is a transmembrane protein expressed and shed from the surface of activated T cells, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes. The LIGHT:TNFRSF14 interaction controls immune response functions by cell death induction as well as cell activation. TNFRSF14 is expressed by peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells. |
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TNFRSF14 Antibody Blocking Peptide(bs-2457P)-500ug
￥880
