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- Bioss
- bs-14545P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-14545P |
| 英文名称 | EIF3S4 Antibody Blocking Peptide |
| 中文名称 | EIF3S4蛋白封闭多肽 |
| 英文别名 | 44kDa; Anti EIF3S4; eIF 3 delta; eIF 3 RNA binding subunit; eIF-3 RNA-binding subunit; eIF-3-delta; eIF3 delta; eIF3 p42; eIF3 p44; eIF3g; EIF3G_HUMAN; EIF3S4; EIF3S4; ; Eukaryotic translation initiation factor 3; Eukaryotic translation initiation factor 3 RNA binding subunit; Eukaryotic translation initiation factor 3 RNA-binding subunit; Eukaryotic translation initiation factor 3 subunit 4; Eukaryotic translation initiation factor 3 subunit 4 delta 44 kD; Eukaryotic translation initiation factor 3 subunit G; Eukaryotic translation initiation factor 3 subunit p42; Subunit 4 (delta 44kD); Subunit 4 delta. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > DNA / RNA > Translation > tRNAs Epigenetics and Nuclear Signaling > RNAi > Eukaryotic Initiation factors (eIF's) |
| 亚细胞定位 | Cytoplasm. Nucleus. Cytoplasm > perinuclear region. Colocalizes with AIFM1 in the nucleus and perinuclear region. |
| 翻译后修饰 | Phosphorylated. Phosphorylation is enhanced upon serum stimulation. |
| 相似性 | Belongs to the eIF-3 subunit G family. Contains 1 RRM (RNA recognition motif) domain. |
| 功能 | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. This subunit can bind 18S rRNA. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The initiation of protein synthesis in eukaryotic cells is regulated by interactions between protein initiation factors and RNA molecules. Eukaryotic initiation factors (eIFs) are utilized in a sequence of reactions that lead to 80S ribosomal assembly and, ultimately, translation. The eukaryotic initiation factor-3 (eIF3) scaffolding structure is the largest of the eIF complexes and includes eIF3 alpha, eIF3 beta, eIF3 gamma, eIF3 delta, all of which function to control the assembly of the 40S ribosomal subunit. Association of eIF3 proteins with the 40S ribosomal subunit stabilizes eIF2-GTP-Met-tRNAiMet complex association and mRNA binding, and promotes dissociation of 80S ribosomes into 40S and 60S subunits, thereby promoting the assembly of the pre-initiation complex. Overexpression of eIF3 proteins is common in several cancers, suggesting a role for eIF3 proteins in tumorigenesis. |
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EIF3S4 Antibody Blocking Peptide(bs-14545P)-500ug
￥880
