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- bs-13332P
- 2026年10月10日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-13332P |
| 英文名称 | GEMC1 Antibody Blocking Peptide |
| 中文名称 | 染色体卷曲螺旋域包含蛋白1封闭多肽 |
| 英文别名 | GEMC1; Geminin coiled coil domain containing protein 1; Gm606; GEMC1_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > DNA / RNA > DNA Synthesis |
| 亚细胞定位 | Nucleus (By similarity). Note=Associates with chromatin during pre-replication complex (pre-RC) formation (By similarity). |
| 翻译后修饰 | Highly phosphorylated by CDK2; stimulates initiation of DNA replication. |
| 相似性 | Belongs to the GEMC1 family._x000D_ |
| 功能 | Regulator of DNA replication. Promotes initiation of chromosomal DNA replication by mediating TOPBP1- and CDK2-dependent recruitment of CDC45L onto replication origins. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | GEMC1 is a 334 amino acid nuclear protein that regulates DNA replication by promoting the recruitment of Cdc45 onto replication origins. A member of the GEMC1 family, GEMC1 is highly phosphorylated and interacts with chromatin during formation of the pre-replication complex. The gene encoding GEMC1 maps to human chromosome 3, which is made up of about 214 million bases encoding over 1,100 genes. Notably, there is a chemokine receptor gene cluster and a variety of human cancer related loci on chromosome 3. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Key tumor suppressing genes on chromosome 3 encode apoptosis mediator RASSF1, cell migration regulator HYAL1 and angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3. |
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GMNC | GEMC1 Ab Blocking Peptide(bs-13332P)-500ug
￥880
