- ￥880
- Bioss
- bs-3844P
- 2026年10月10日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-3844P |
| 英文名称 | eIF6 Antibody Blocking Peptide |
| 中文名称 | β4整合素结合蛋白封闭多肽 |
| 英文别名 | b(2)gcn; B(2)GCN homolog; B4 integrin interactor; Binding protein of beta-4 integrin; CAB; eIF-6; EIF3A; Eukaryotic translation initiation factor 3A; Eukaryotic translation initiation factor 6; IF6_HUMAN; ITGB4BP; OK/SW-cl.27; p27 beta 4 integrin binding protein; p27(BBP); p27BBP; RP4-614O4.1. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Transcription > Mediator Complex Neuroscience > Cell Adhesion Proteins > Receptors > Integrins > Beta Integrins |
| 亚基 | Belongs to the eIF-6 family. |
| 亚细胞定位 | Cytoplasm. Nucleus. nucleolus. Shuttles between cytoplasm and nucleus/nucleolus. |
| 组织特异性 | Expressed at very high levels in colon carcinoma with lower levels in normal colon and ileum and lowest levels in kidney and muscle (at protein level). |
| 翻译后修饰 | Phosphorylation at Ser-174 and Ser-175 by CSNK1D/CK1 promotes nuclear export. |
| 相似性 | Belongs to the eIF-6 family. |
| 功能 | Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by Intergrin beta 4 binding protein binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple transcript variants encoding several different isoforms have been found for this gene. |
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EIF6 | eIF-6 Ab Blocking Peptide(bs-3844P)-500ug
￥880
