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- Bioss
- bs-13313P
- 2026年10月10日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-13313P |
| 英文名称 | GCHFR Antibody Blocking Peptide |
| 中文名称 | GTP环反馈调节蛋白封闭多肽 |
| 英文别名 | GCHFR; GFRP; GFRP_HUMAN; GTP cyclohydrolase 1 feedback regulatory protein; GTP cyclohydrolase I feedback regulator; GTP cyclohydrolase I feedback regulatory protein; HsT16933; MGC138467; MGC138469; p35. |
| 纯化方法 | HPLC |
| 亚基 | Homopentamer. Forms a complex with GCH1 where a GCH1 homodecamer is sandwiched by two GFRP homopentamers (By similarity). Interacts with GCH1. |
| 亚细胞定位 | Nucleus. Nucleus membrane. Cytoplasm; cytosol. |
| 组织特异性 | In epidermis, expressed predominantly in basal undifferentiated keratinocytes and in some but not all melanocytes (at protein level). |
| 相似性 | Belongs to the GFRP family. |
| 功能 | Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | GTP cyclohydrolase I feedback regulatory protein (GFRP) is encoded by the gene GCHFR. GFRP mediates feedback inhibition of GTP cyclohydrolase I activity by tetrahydrobiopterin. GFRP also acts as a mediator for the stimulatory effect of phenylalanine on enzyme activity. L-phenylalanine reverses this inhibition. The molecular weight of GFRP is approximately 9.5kDa although cross-linking experiments have shown that GFRP is usually found as a homodimer or as a pentamer. 15q15. |
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GCHFR | GFRP Ab Blocking Peptide(bs-13313P)-500ug
￥880
