- ￥880
- Bioss
- bs-3824P
- 2026年10月10日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-3824P |
| 英文名称 | KDM3B Antibody Blocking Peptide |
| 中文名称 | 组蛋白去甲基转移酶JMJD1B封闭多肽 |
| 英文别名 | JHDM2B; JmjC domain containing histone demethylation protein 2B; JmjC domain-containing histone demethylation protein 2B ; jmjd1b; Jumonji domain containing protein 1B; JUMONJI DOMAIN-CONTAINING PROTEIN 1B ; KDM3B; KDM3B_HUMAN; Lysine-specific demethylase 3B; Nuclear protein 5qNCA. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Oncoproteins/suppressors > Tumor suppressors Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > Jumonji containing proteins Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > Methylation Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > Methylation > Lysine demethylation Epigenetics and Nuclear Signaling > Transcription > Domain Families > Zinc Finger |
| 亚细胞定位 | Nucleus. |
| 组织特异性 | Ubiquitous. Highly expressed in placenta, skeletal muscle, kidney, heart and liver. |
| 相似性 | Belongs to the JHDM2 histone demethylase family. Contains 1 JmjC domain._x000D_ |
| 功能 | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | JMJD1B (jumonji domain containing 1B), also known as KDM3B, 5qNCA (5q Nuclear Co-Activator) or C5orf7, is a member of the JHDM2 histone demethylase family of proteins. Expressed in a wide variety of tissues, JMJD1B localizes to the nucleus and contains one JMJC domain and a C-terminal zinc finger motif. JMJD1B functions as a histone demethylase and, using iron as a cofactor, demethylates lysine-9 of Histone H3. This suggests that JMJD1B plays a central role in the histone code. The gene encoding human JMJD1B is located within the 5q region of the genome that is often deleted in myeloid leukemias and myelodysplasias. This implies that JMJD1B may function as a tumor suppressor of myeloid leukemia. Eptopic expression of JMJD1B exhibits growth suppressive activities, further supporting a role for JMJD1B in tumor suppression. |
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KDM3B | JMJD1B Ab Blocking Peptide(bs-3824P)-500ug
￥880
