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- bs-17248P
- 2025年10月16日
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500ug
| 产品编号 | bs-17248P |
| 英文名称 | SBF1 Antibody Blocking Peptide |
| 中文名称 | 肌微管蛋白MTMR5封闭多肽 |
| 英文别名 | SBF1; C22:RP4-579N16.2; CMT4B3; MTMR5_HUMAN; DENN/MADD domain containing 7A; DENND7A; MTMR5; Myotubularin related 5; Myotubularin-related protein 5; SET-binding factor 1. |
| 纯化方法 | HPLC |
| 研究领域 | Signal Transduction > Protein Phosphorylation > Tyrosine Phosphatases |
| 亚基 | Interacts with the SET domain of KMT2A/MLL1. Interacts with SUV39H1. |
| 亚细胞定位 | Nuclear |
| 相似性 | Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. Contains 1 dDENN domain. Contains 1 DENN domain. Contains 1 GRAM domain. Contains 1 myotubularin phosphatase domain. Contains 1 PH domain. Contains 1 uDENN domain. |
| 功能 | Probable pseudophosphatase. Lacks several amino acids in the catalytic pocket which renders it catalytically inactive as a phosphatase. The pocket is however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases. Inhibits myoblast differentiation in vitro and induces oncogenic transformation in fibroblasts. According to PubMed:20937701, may function as a guanine nucleotide exchange factor (GEF) activating RAB28. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Probable pseudophosphatase. Lacks several amino acids in the catalytic pocket which renders it catalytically inactive as a phosphatase. The pocket is however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases. Inhibits myoblast differentiation in vitro and induces oncogenic transformation in fibroblasts. May function as a guanine nucleotide exchange factor (GEF) activating RAB28. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. |
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文献和实验or from the literature are missing. In this article, processing parameters for DNA, peptide, antibody, and carbohydrate microarrays are outlined. The applicability of the model experiments is demonstrated and described in detail on the example of short oligonucleotides.
Synthesis and Probing of Membrane-bound Peptide Arrays
the stringency of the blocking conditions and make sure that the primary binding partner and detection reagent (e.g., antibody) are of high purity and are used in the highest possible dilution. Stage
Mapping Protein‐Protein Interactions with Phage‐Displayed Combinatorial Peptide Libraries
. Fack, F., Deroo, S., Kreis, S., and Muller, C.P. 2000. Heteroduplex mobility assay (HMA) pre‐screening: An improved strategy for the rapid identification of inserts selected from phage‐displayed peptide
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