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| 产品编号 | bs-12046P |
| 英文名称 | 5HT1D Receptor/SR-1D Antibody Blocking Peptide |
| 中文名称 | 5-羟色胺受体1D封闭多肽 |
| 英文别名 | SR-1D; 5 HT 1D alpha; 5 HT 1D; 5 HT1B; 5 HT1D; 5HT1D; 5 hydroxytryptamine (serotonin) receptor 1B; 5 hydroxytryptamine (serotonin) receptor 1D G protein coupled; 5 hydroxytryptamine 1B receptor (5 HT 1B) (Serotonin receptor) (5 HT 1D beta) (Serotonin 1D beta receptor) (S12); 5 hydroxytryptamine receptor 1D; HT1DA; HTR1D; HTR1D2; HTR1DA; HTRL; RDC4; S12; Serotonin receptor 1D; 5HT1D_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Metabolism > Types of disease > Obesity Neuroscience > Neurotransmission > Receptors / Channels > GPCR > Serotonin Receptors |
| 亚细胞定位 | Cell membrane; Multi-pass membrane protein |
| 相似性 | Belongs to the G-protein coupled receptor 1 family. |
| 功能 | This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The members of the G-protein-coupled receptor family are distinguished by their slow transmitting response to ligand binding. These seven transmembrane proteins include the adrenergic, serotonin and dopamine receptors. The effect of the signaling molecule can be excitatory or inhibitory depending on the type of receptor to which it binds. b-adrenergic bound to adrenaline activates adenylyl cyclase, while a2-adrenergic receptor bound to adrenaline inhibits adenylyl cyclase. Like the a2-adrenergic receptor, serotonin receptor functions are also mediated by G proteins that inhibit the activity of adenylyl cyclase. The serotonin receptors have been classified into several categories, designated SR-1–7 (5HT1–7). Subtypes within the SR-1 group include SR-1A, -1B, -1D, -1E and -1F. |
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文献和实验【申请上传】Current Protocols in Immunology
Motifs, and Expression of Nonclassical Class I and Related Genes and Molecules 1N Overview of Protein Folds in the Immune System1 1O Nomenclature of the Human T Cell Receptor Genes 1P Nomenclature of the Human Immunoglobulin Genes 1Q Safe Use
自体活性物质（autacoids）又称局部激素，多数是机体受到伤害性刺激后产生，以旁分泌方式到达邻近部位发挥作用。它们在局部合成后，不进入血液循环，主要在合成部位附近发挥作用，且半衰期短暂。组胺（histamine）、前列腺素（prostaglandin, PG）、白三烯（leukotriene）、5-羟色胺（5-HTA）和血管活性肽类（vasoactive peptide）、P物质（substance P）、激肽类（kinins）、血管紧张素（angiotensin
Murphy, K.P., Xie, D., Garcia, K.C., Amzel, L.M., and Freire, E. 1993. Structural energetics of peptide recognition: Angiotensin II/antibody binding. Proteins Struct. Funct. Genet. 15:113‐120.
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