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- 技术资料
- 规格:
500ug
| 产品编号 | bs-3689P |
| 英文名称 | IL3RB Antibody Blocking Peptide |
| 中文名称 | 粒细胞-巨噬细胞集落刺激因子受体β封闭多肽 |
| 英文别名 | IL3RB; IL-3RB; IL-3R beta; GM-CSFR Beta; IL 3 receptor beta; IL-5RB; IL-5R beta; IL 5 receptor beta; GM-CSFrβ; GM-CSF receptor beta chain; GM-CSF/IL-3/IL-5 receptor common beta subunit; CSF2RB; IL3RB; IL5RB; GM CSF/IL 3/IL 5 receptor common beta chain; GM CSF/IL 3/IL 5 receptor common beta-chain; IL3RB; CD131; CDw131; Colony stimulating factor 2 receptor beta; Colony stimulating factor 2 receptor beta low affinity (granulocyte macrophage); Colony stimulating factor 2 receptor beta low-affinity (granulocyte macrophage); CSF2RB; Cytokine receptor common beta chain; Cytokine receptor common beta chain precursor (CDw131 antigen); Cytokine receptor common subunit beta; GM-CSF/IL-3/IL-5 receptor common beta subunit; IL3RB_HUMAN; IL5RB; Interleukin 3 receptor/granulocyte macrophage colony stimulating factor 3 receptor beta (high affinity); Interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3 receptor beta (high affinity); stimulating factor 3 receptor, beta (high affinity). |
| 纯化方法 | HPLC |
| 研究领域 | Immunology > Immunoglobulins > Receptors |
| 亚基 | Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits. Interacts with TMEM102; this interaction occurs preferentially in the absence of CSF2. Interacts with LYN. |
| 亚细胞定位 | Membrane; Single-pass type I membrane protein. |
| 组织特异性 | Defects in CSF2RB are the cause of pulmonary surfactant metabolism dysfunction type 5 (SMDP5) [MIM:614370]. SMDP5 is a rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. |
| 翻译后修饰 | May be phosphorylated by LYN. |
| 相似性 | Belongs to the type I cytokine receptor family. Type 4 subfamily. Contains 2 fibronectin type-III domains. |
| 功能 | High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | GM-CSF Receptor Beta is the v subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Six transcript variants encoding five different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble. |
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CSF2RB | IL3RB Ab Blocking Peptide(bs-3689P)-500ug
¥880






