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- 2025年10月16日
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500ug
| 产品编号 | bs-3689P |
| 英文名称 | IL3RB Antibody Blocking Peptide |
| 中文名称 | 粒细胞-巨噬细胞集落刺激因子受体β封闭多肽 |
| 英文别名 | IL3RB; IL-3RB; IL-3R beta; GM-CSFR Beta; IL 3 receptor beta; IL-5RB; IL-5R beta; IL 5 receptor beta; GM-CSFrβ; GM-CSF receptor beta chain; GM-CSF/IL-3/IL-5 receptor common beta subunit; CSF2RB; IL3RB; IL5RB; GM CSF/IL 3/IL 5 receptor common beta chain; GM CSF/IL 3/IL 5 receptor common beta-chain; IL3RB; CD131; CDw131; Colony stimulating factor 2 receptor beta; Colony stimulating factor 2 receptor beta low affinity (granulocyte macrophage); Colony stimulating factor 2 receptor beta low-affinity (granulocyte macrophage); CSF2RB; Cytokine receptor common beta chain; Cytokine receptor common beta chain precursor (CDw131 antigen); Cytokine receptor common subunit beta; GM-CSF/IL-3/IL-5 receptor common beta subunit; IL3RB_HUMAN; IL5RB; Interleukin 3 receptor/granulocyte macrophage colony stimulating factor 3 receptor beta (high affinity); Interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3 receptor beta (high affinity); stimulating factor 3 receptor, beta (high affinity). |
| 纯化方法 | HPLC |
| 研究领域 | Immunology > Immunoglobulins > Receptors |
| 亚基 | Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits. Interacts with TMEM102; this interaction occurs preferentially in the absence of CSF2. Interacts with LYN. |
| 亚细胞定位 | Membrane; Single-pass type I membrane protein. |
| 组织特异性 | Defects in CSF2RB are the cause of pulmonary surfactant metabolism dysfunction type 5 (SMDP5) [MIM:614370]. SMDP5 is a rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. |
| 翻译后修饰 | May be phosphorylated by LYN. |
| 相似性 | Belongs to the type I cytokine receptor family. Type 4 subfamily. Contains 2 fibronectin type-III domains. |
| 功能 | High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | GM-CSF Receptor Beta is the v subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Six transcript variants encoding five different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble. |
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文献和实验or from the literature are missing. In this article, processing parameters for DNA, peptide, antibody, and carbohydrate microarrays are outlined. The applicability of the model experiments is demonstrated and described in detail on the example of short oligonucleotides.
Synthesis and Probing of Membrane-bound Peptide Arrays
the stringency of the blocking conditions and make sure that the primary binding partner and detection reagent (e.g., antibody) are of high purity and are used in the highest possible dilution. Stage
Mapping Protein‐Protein Interactions with Phage‐Displayed Combinatorial Peptide Libraries
. Fack, F., Deroo, S., Kreis, S., and Muller, C.P. 2000. Heteroduplex mobility assay (HMA) pre‐screening: An improved strategy for the rapid identification of inserts selected from phage‐displayed peptide
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