- ￥880
- Bioss
- bs-12011P
- 2026年10月10日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-12011P |
| 英文名称 | GRM Antibody Blocking Peptide |
| 中文名称 | 代谢型谷氨酸受体1A封闭多肽 |
| 英文别名 | G protein coupled receptor family C group 1 member A; Glutamate receptor metabotropic 1 alpha; Glutamate receptor metabotropic 1; GPRC1A; GRM 1; GRM1 alpha; GRM1; GRM1A; Human metabotropic glutamate receptor 1 alpha mRNA complete cds; Metabotropic glutamate receptor 1 alpha; Metabotropic glutamate receptor 1; mGlu1; MGLUR1; MGLUR1A; mGluR1alpha; metabotropic glutamate receptor 1 isoform alpha; GRM1_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Neurotransmission > Receptors / Channels > GPCR > Glutamate Receptors |
| 亚基 | Homodimer; disulfide-linked. The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP. |
| 亚细胞定位 | Cell membrane; Multi-pass membrane protein. |
| 相似性 | Belongs to the G-protein coupled receptor 3 family. |
| 功能 | Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which may have distinct functions. [provided by RefSeq]. |
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GRM1 | mGluR1 Ab Blocking Peptide(bs-12011P)-500ug
￥880
