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- 2025年10月16日
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500ug
| 产品编号 | bs-8630P |
| 英文名称 | SWAP70 Antibody Blocking Peptide |
| 中文名称 | 开关相关蛋白70封闭多肽 |
| 英文别名 | KIAA0640; 70kDa; AV235546; FLJ39540; HSPC321; SWA 70 protein; SWAP 70; SWAP switching B-cell complex 70kDa subunit; SWAP-70; Switch associated protein 70; Switch-associated protein 70; SWP70_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Immunology > Immunoglobulins > Class Switching Signal Transduction > Signaling Pathway > Calcium Signaling > Calcium Binding Proteins |
| 亚细胞定位 | Cytoplasm. Cell membrane. Nucleus. Cell projection > lamellipodium. In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus. In activated, class-switching B-cells it is associated with membrane IgG but not IgM. Localized to loose actin filament arrays located behind actively extending lamellipodia. |
| 组织特异性 | Expressed only in mature B-cells including those associated with mucosa-associated tissue and bronchus-associated tissue (PubMed:10681448). Widely expressed. Abundant in spleen, and fairly abundant in kidney, lung and liver. Also found in monocytes and macrophages (PubMed:12925760). |
| 翻译后修饰 | Tyrosine-phosphorylated. |
| 相似性 | Contains 1 PH domain. |
| 功能 | Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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文献和实验or from the literature are missing. In this article, processing parameters for DNA, peptide, antibody, and carbohydrate microarrays are outlined. The applicability of the model experiments is demonstrated and described in detail on the example of short oligonucleotides.
Synthesis and Probing of Membrane-bound Peptide Arrays
the stringency of the blocking conditions and make sure that the primary binding partner and detection reagent (e.g., antibody) are of high purity and are used in the highest possible dilution. Stage
Mapping Protein‐Protein Interactions with Phage‐Displayed Combinatorial Peptide Libraries
. Fack, F., Deroo, S., Kreis, S., and Muller, C.P. 2000. Heteroduplex mobility assay (HMA) pre‐screening: An improved strategy for the rapid identification of inserts selected from phage‐displayed peptide
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