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- bs-1719P
- 2026年10月10日
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500ug
| 产品编号 | bs-1719P |
| 英文名称 | HPV16/18 protein Antibody Blocking Peptide |
| 中文名称 | 人类乳头状瘤病毒16/18 E6封闭多肽 |
| 英文别名 | HPV16+HPV18 E6; HPV16/18 protein; Human Papilloma virus; E6; Human papillomavirus type 16 E6; Human papillomavirus type 18 E6; Protein E6 . |
| 纯化方法 | HPLC |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer. HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among the low risk types. Approximately 90% of cervical cancers contain HPV DNA of the high risk types. Mutational analysis have shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro. Human papillomaviruses (HPV) are small DNA viruses which infect epithelia of the skin and mucosa. Over 90 types have been identified and they mostly cause a variety of benign lesions such as warts and verrucae. However, some subtypes, notably types 16 and 18, 31 and 33, have been confirmed as agents which cause cervical cancer. |
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文献和实验相关实验
连接形成bcr-abl融合基因编码210KD融合蛋白（p210 bcr-abl），这种蛋白可被T细胞识别。2致癌病毒性基因产物：如人乳头瘤状病毒（HPV）的16和18型与宫颈癌密切相关，HPV16的E6、E7基因能使宫颈鳞状上皮转化为肿瘤细胞。而E6、E7的基因产物可被T细胞识别。3其他: 如MUC-I基因编码的与细胞膜相关的粘蛋白，在某些癌细胞中高表达，关键是糖基化不完全，而暴露出多肽骨架，成为免疫识别的靶子，并且属于MHC非限制性的肿瘤相关抗原。从严格的定义来讲，肿瘤抗原并不绝对是肿瘤特异性抗原
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HPV16 | E6 Ab Blocking Peptide(bs-1719P)-500ug
￥880
