- ￥1350 - 3000
- Proteintech
- 28007-1-AP
- 2025年10月14日
- WB, IHC, ELISA
- Rabbit
- Human, Mouse, canine
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Recombinant human MAPK10 protein
- 亚型：
IgG
- 保存条件：
Store at -20°C. Stable for one year after shipment.
- 克隆性：
Polyclonal
- 标记物：
Unconjugated
- 适应物种：
Human, Mouse, canine
- 保质期：
详见产品包装
- 库存：
充足
- 宿主：
Rabbit
- 应用范围：
WB, IHC, ELISA
- 靶点：
JNK
- 抗体英文名：
JNK Polyclonal antibody
- 抗体名：
JNK Polyclonal antibody
- 规格：
50ul/100ul/150ul
| 规格： | 50ul | 产品价格： | ￥1350.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥2200.0 |
| 规格： | 150ul | 产品价格： | ￥3000.0 |
经过测试的应用
| Positive WB detected in | Neuro-2a cells, MDCK cells, mouse brain tissue, mouse cerebellum tissue |
| Positive IHC detected in | mouse brain tissue, mouse cerebellum tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Western Blot (WB) | WB : 1:1000-1:4000 |
| Immunohistochemistry (IHC) | IHC : 1:50-1:500 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
28007-1-AP targets JNK in WB, IHC, ELISA applications and shows reactivity with Human, Mouse, canine samples.
| 经测试应用 | WB, IHC, ELISA |
| 文献引用应用 | WB |
| 经测试反应性 | Human, Mouse, canine |
| 文献引用反应性 | human, mouse, rat |
| 免疫原 |
CatNo: Ag27823 Product name: Recombinant human MAPK10 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 271-408 aa of BC065516 Sequence: QWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNG |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | mitogen-activated protein kinase 10 |
| 别名 | c Jun N terminal kinase 3, FLJ12099, FLJ33785, JNK, JNK1, JNK1/2/3, JNK2, JNK3, JNK3A, MAP kinase 10, MAP kinase p49 3F12, MAPK 10, MAPK10, MAPK8, MAPK8/9/10, MAPK9, p493F12, p54bSAPK, PRKM10 |
| 计算分子量 | 464 aa, 53 kDa |
| 观测分子量 | 45-48 kDa, 54-57 kDa |
| GenBank蛋白编号 | BC065516 |
| 基因名称 | JNK3 |
| Gene ID (NCBI) | 5602 |
| RRID | AB_2881035 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | P53779 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
JNK, also named MAPK10 (mitogen-activated protein kinase 10), belongs to MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is mainly expressed in a subset of neurons in the nervous system, and is activated by threonine and tyrosine phosphorylation. JNK has 3 isoforms of 48-53 kDa.
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文献和实验| Species | Application | Title |
|---|---|---|
| rat | WB | Sci Total Environ Exploring potential targets and mechanisms of renal tissue damage caused by N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone (6-PPDQ) through network toxicology and animal experiments: A case of chronic kidney diseaseAuthors - Jun Pei |
| rat | WB | Front Immunol Identification of ALDH2 as a novel target for the treatment of acute kidney injury in kidney transplantation based on WGCNA and machine learning algorithms and exploration of its potential mechanism of action using animal experimentsAuthors - Jinpu Peng |
| mouse | WB | Int J Biol Macromol VSIG4 inhibits RANKL-induced osteoclastogenesis by enhancing Nrf2-dependent antioxidant response against reactive oxygen species productionAuthors - Jiansen Miao |
| human | WB | Int Immunopharmacol Molecular mechanisms and potential targets of lycopene for alleviating renal ischemia-reperfusion injury revealed by network pharmacology and animal experimentsAuthors - Xingyu Pan |
| human | WB | Nat Commun SARS-CoV-2 N protein-induced Dicer, XPO5, SRSF3, and hnRNPA3 downregulation causes pneumoniaAuthors - Yu-Wei Luo |
双磷酸化而提高其转录活性。c―jun是激活蛋白―1(AP―1)复合体的一个组成部分，在包括细胞增殖、分化和肿瘤转化等过程中起重要作用。JNK家族在调节细胞的应激反应基因的转录和翻译过程中起作用。激活的JNK可调控许多3’末端翻译区域(UTR)富含AU元件(AURE)基因的半衰期，从而增强这些基因mRNA的翻译过程。另外，激活的JNK还能通过激活内源性通路，使Bcl―2和Bcl―XI。参与促凋亡分子的释放(例如从线粒体释放细胞色素C)，从而导致caspase的激活和细胞凋亡。JNK还参与了对c―jun
位的丝氨酸残基磷酸化，进而激活c-Jun而增强其转录活性[7]。c-Jun氨基末端的磷酸化还可以促进c-Jun/c-Fos异二聚体及c-Jun同二聚体的形成，这些转录因子可以结合到许多基因启动子区AP-1位点，增加特定基因的转录活性。此外，JNK/SAPK激活后还可以使转录因子Elk-1和ATF2发生磷酸化，并使其转录活性增强。 本信号转导涉及的信号分子 主要包括： CrkL，Shc，GRB2，JNK，JNK1，JNK2，JNK3，MKK4，MKK7，IRS-1，c
and induces immune paralysis. Activation of JNK/c-Jun signaling pathway by various stimuli often leads to a formation of the AP-1 transcriptional complex, which is a critical regulator of a complex program of gene expression that defines the invasive phenotype
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