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- 2025年10月15日
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| 产品编号 | IHC0637R |
| 英文名称 | Rat AP2 alpha Ready-To-Use IHC Kit |
| 中文名称 | 大鼠转录激活蛋白2α/TFAP2α/AP-2α即用型免疫组化试剂盒 |
| 英文别名 | Ap-2 (a); AP-2alpha; Ap2; AP2alpha; Tcfap2a; TFAP2; Activating enhancer binding protein 2 alpha; Activating enhancer-binding protein 2-alpha; Activator protein 2; AP 2 transcription factor; AP 2alpha; AP-2; AP-2 transcription factor; AP2; AP2 Transcription Factor; AP2-alpha; AP2A_HUMAN; AP2TF; BOFS; FLJ51761; TFAP 2; TFAP 2A; TFAP2; TFAP2A; Transcription factor AP 2 alpha (activating enhancer binding protein 2 alpha); Transcription factor AP-2-alpha; Transcription factor AP2 alpha |
| 产品应用 | IHC-P Not yet tested in other applications. |
| 交叉反应 | Rat |
| 亚基 | Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. Interacts with WWOX. Interacts with CITED4. Interacts with UBE2I. Interacts with RALBP1 in a complex also containing EPN1 and NUMB during interphase and mitosis. Interacts with KCTD1; this interaction represses transcription activation. Interacts (via C-terminus) with CITED2 (via C-terminus); the interaction stimulates TFAP2A-transcriptional activation. Interacts (via N-terminus) with EP300 (via N-terminus); the interaction requires CITED2. Interacts with KCTD15; this interaction inhibits TFAP2A transcriptional activation.9 Publications |
| 亚细胞定位 | Nucleus |
| 翻译后修饰 | Sumoylated on Lys-10; which inhibits transcriptional activity. |
| 相似性 | Belongs to the AP-2 family. |
| 功能 | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. |
| 保存条件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 背景资料 | TFAP2A is a sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limbs and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. TFAP2A is the only AP-2 protein required for early morphogenesis of the lens vesicle. |
| 应用 | 推荐稀释比例 |
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文献和实验PriCells: Introduction of Isolation and Culture of Human Alveolar Epithelial Cells
and some ethical issues pertaining to use of human tissues in certain countries, most studies were based on isolation and culture of cells from the lungs of small laboratory animals including mouse, rat, and rabbit. However, not much information on species
Immunohistochemistry / Immunocytochemistry Procedures
) and Mouse anti-NF-L (Cat No. MAB1615 ) staining of cultured rat neurons. Mature neurons are green (NF-L positive) and neuronal progenitor cells are red (alpha-internexin positive
免疫组化技术-Immunohistochemical Protocols
, Vectastain ABC Elite kit, Vector Laboratories, Burlingame, CA) at dilutions of 1:250 "A" and 1:250 "B" in BSA diluent, prepared at least 30 min before use for 1 hr. (The ABC reagent can be equivalently replaced by streptavidin-HRP (Table 2) at a dilution
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