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- IHC0489H
- 2025年10月15日
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- 详细信息
- 技术资料
- 规格：
50T
| 产品编号 | IHC0489H |
| 英文名称 | Human ZEB1 Ready-To-Use IHC Kit |
| 中文名称 | 人负调控因子白细胞介素2即用型免疫组化试剂盒 |
| 英文别名 | 3110032K11Rik; [delta]EF1; AREB6; BZP; DELTAEF1; FECD6; MEB1; Nil2; NIL2A; PPCD3; TCF-8; Tcf18; TCF8; Tw; ZEB; ZEB1; ZFHEP; ZFHX1A; Zfx1a; Zfx1ha |
| 产品应用 | IHC-P Not yet tested in other applications. |
| 交叉反应 | Human |
| 亚基 | Interacts (via N-terminus) with SMARCA4/BRG1. |
| 亚细胞定位 | #Nucleus |
| 组织特异性 | Colocalizes with SMARCA4/BRG1 in E-cadherin-negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas (at protein level). Expressed in heart and skeletal muscle, but not in liver, spleen, or pancreas. |
| 翻译后修饰 | Ubiquitinated, leading to degradation in a proteasome-dependent manner. Deubiquitinated by USP51, leading to stabilization. |
| 相似性 | Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family. |
| 功能 | Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region (By similarity). |
| 保存条件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 背景资料 | ZEB1 (Zinc finger E-box-binding homeobox 1) acts as a transcriptional repressor. It inhibits interleukin-2 (IL-2) gene expression. ZEB1 enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and depending on the cell type. It represses E-cadherin promoters and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. ZEB1 also represses BCL6 transcription in the presence of the corepressor CTBP1. It postively regulates neuronal differentiation and represses RCOR1 transcription activation during neurogenesis. Mutations in the gene can result in corneal dystrophy, posterior polymorphous and corneal dystrophy, Fuchs endothelial 6. |
| 应用 | 推荐稀释比例 |
Immunohistochemical analysis of paraffin embedded human ovarian cancer tissue slide using IHC0489H (Human ZEB1 IHC Kit).
Immunohistochemical analysis of paraffin embedded human pancreas tissue slide using IHC0489H (Human ZEB1 IHC Kit).
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Human ZEB1 Ready-To-Use IHC Kit(IHC0489H)-50T
￥3200
