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- IHC0479H
- 2025年10月15日
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50T
| 产品编号 | IHC0479H |
| 英文名称 | Human SOD2 Ready-To-Use IHC Kit |
| 中文名称 | 人超氧化物歧化酶2即用型免疫组化试剂盒 |
| 英文别名 | IPO-B; IPOB; Mn-SOD; MNSOD; MVCD6; SOD2 |
| 产品应用 | IHC-P Not yet tested in other applications. |
| 交叉反应 | Human |
| 亚基 | Homotetramer. |
| 亚细胞定位 | #Mitochondrion |
| 组织特异性 | Expression is regulated by KRIT1. |
| 翻译后修饰 | Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity. Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting (By similarity). Polyubiquitinated; leading to proteasomal degradation. Deubiquitinated by USP36 which increases protein stability. |
| 相似性 | Belongs to the iron/manganese superoxide dismutase family. |
| 功能 | Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. |
| 保存条件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 背景资料 | Superoxide dismutase (SOD) is an antioxidant enzyme involved in the defense system against reactive oxygen species (ROS). SOD catalyzes the dismutation reaction of superoxide radical anion (O2) to hydrogen peroxide, which is then catalyzed to innocuous O2 and H2O by glutathione peroxidase and catalase. Several classes of SOD have been identified. These include intracellular copper, zinc SOD (Cu, Zn-SOD/SOD-1), mitochondrial manganese SOD (Mn-SOD/SOD-2) and extracellular Cu, Zn-SOD (EC-SOD/SOD-3). SOD1 is found in all eukaryotic species as a homodimeric 32 kDa enzyme containing one each of Cu and Zn ion per subunit. The manganese containing 80 kDa tetrameric enzyme SOD2, is located in the mitochondrial matrix in close proximity to a primary endogenous source of superoxide, the mitochondrial respiratory chain. SOD3 is a heparin-binding multimer of disulfide-linked dimers, primarily expressed in human lungs, vessel walls and airways. SOD4 is a copper chaperone for superoxide dismutase (CCS), which specifically delivers Cu to copper/zinc superoxide dismutase. CCS may activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor. |
| 应用 | 推荐稀释比例 |
Immunohistochemical analysis of paraffin embedded human liver tissue slide using IHC0479H (Human SOD2 IHC Kit).
Immunohistochemical analysis of paraffin embedded human skeletal muscle tissue slide using IHC0479H (Human SOD2 IHC Kit).
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Human SOD2 Ready-To-Use IHC Kit(IHC0479H)-50T
￥3200
