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- IHC0293H
- 2025年10月15日
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50T
| 产品编号 | IHC0293H |
| 英文名称 | Human CD34 Ready-To-Use IHC Kit |
| 中文名称 | 人CD34即用型免疫组化试剂盒 |
| 英文别名 | CD34; CD34 antigen; CD34 molecule; Cluster designation 34; Hematopoietic progenitor cell antigen CD34; HPCA1; CD34_HUMAN |
| 产品应用 | IHC-P Not yet tested in other applications. |
| 交叉反应 | Human |
| 亚细胞定位 | Membrane |
| 组织特异性 | Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues. |
| 翻译后修饰 | Highly glycosylated. Phosphorylated on serine residues by PKC. |
| 相似性 | Belongs to the CD34 family. |
| 功能 | Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins. |
| 保存条件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | CD34 is a highly glycosylated monomeric with a molecular weight range of 111-115 kDa surface protein that is present on many stem cell populations. CD34 is a stem cell marker although its expression on human hematopoietic stem cells is reversible. CD34 may serve as a surface receptor that undergoes receptor-mediated endocytosis and regulates adhesion, differentiation and proliferation of hematopoietic stem cells and other progenitors. CD34 expression is likely to represent a specific state of hematopoietic development that may have altered adhering properties with expanding and differentiating capabilities in both in vitro and in vivo conditions. CD34 is possibly an adhesion molecule with a putative role for mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Further, CD34 could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C suggesting a putative role in signal transduction. Diseases associated with CD34 dysfunction include dermatofibrosarcoma and neurofibroma. |
| 应用 | 推荐稀释比例 |
Immunohistochemical analysis of paraffin embedded human tonsil tissue slide using IHC0293H (Human CD34 IHC Kit).
Immunohistochemical analysis of paraffin embedded human lung tissue slide using IHC0293H (Human CD34 IHC Kit).
Immunohistochemical analysis of paraffin embedded human brain tissue slide using IHC0293H (Human CD34 IHC Kit).
Immunohistochemical analysis of paraffin embedded human placenta tissue slide using IHC0293H (Human CD34 IHC Kit).
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Human CD34 Ready-To-Use IHC Kit(IHC0293H)-50T
￥3200
