Mouse Cytochrome C Ready-To-Use IHC Kit(IHC0117M)-50T产品图

Mouse Cytochrome C Ready-To-Us

e IHC Kit(IHC0117M)-50T
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  • ¥3200
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  • IHC0117M
  • 2025年10月15日
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      50T

    产品编号 IHC0117M
    英文名称 Mouse Cytochrome C Ready-To-Use IHC Kit
    中文名称 小鼠细胞色素C即用型免疫组化试剂盒
    产品应用 IHC-P

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应 Mouse
    性状 Liquid
    研究领域

    Cancer > Cancer Metabolism > Metabolic signaling pathway > Integration of energy metabolism

    Cancer > Cell Death > Apoptosis > Apoptosis Markers > Cytochrome C

    Cancer > Cell Death > Apoptosis > Metabolism

    Cancer > Cell Death > Apoptosis > Mitochondrial

    Cancer > Invasion/microenvironment > Apoptosis > Cytochrome C

    Cardiovascular > Lipids / Lipoproteins > Lipid Metabolism > Cytochromes

    Cell Biology > Apoptosis > Mitochondrial

    Metabolism > Pathways and Processes > Metabolic signaling pathways > Energy transfer pathways > Energy Metabolism

    Metabolism > Pathways and Processes > Metabolic signaling pathways > Energy transfer pathways > Integration of energy

    Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Lipases

    Metabolism > Pathways and Processes > Metabolism processes > Apoptosis

    Metabolism > Pathways and Processes > Mitochondrial Metabolism > Cytochromes

    Metabolism > Pathways and Processes > Mitochondrial Metabolism > Mitochondrial markers

    Metabolism > Pathways and Processes > Mitochondrial Metabolism > Oxidative phosphorylation

    Signal Transduction > Metabolism > Energy Metabolism

    Signal Transduction > Metabolism > Mitochondrial

    亚细胞定位

    Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.

    翻译后修饰

    Binds 1 heme c group covalently per subunit.
    Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration.

    相似性

    Belongs to the cytochrome c family.

    功能

    Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
    Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

    保存条件 Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt.
    注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料 Cytochrome C is an electron transporting protein that resides within the intermembrane space of the mitochondria, where it plays a critical role in the process of oxidative phosphorylation and production of cellular ATP. An increasing amount of interest has been directed toward the role which cytocrome C has been demonstrated to play in apoptotic processes. Following exposure to apoptotic stimuli, cytochrome C is rapidly released from the mitochondria into the cytosol, an event which may be required for the completion of apoptosis in some systems. Cytosolic cytochrome C functions in the activation of caspase 5, an ICE family molecule that is a key effector of apoptosis.

     

    应用 推荐稀释比例

     

    Immunohistochemical analysis of paraffin embedded mouse heart tissue slide using IHC0117M (Mouse Cytochrome C IHC Kit).

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