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| 规格: | 20ug | 产品价格: | ¥980.0 |
|---|---|---|---|
| 规格: | 50ug | 产品价格: | ¥1880.0 |
| 规格: | 100ug | 产品价格: | ¥2680.0 |
| 产品编号 | bs-106502P |
| 英文名称 | Recombinant Mouse CTSK Protein, N-His |
| 英文别名 | Cathepsin K; 3.4.22.38; Ctsk |
| 性状 | Lyophilized |
| 纯化方法 | AC |
| 理论分子量 | 29.53 kDa |
| 储存液 | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| 亚基 | Belongs to the peptidase C1 family. |
| 亚细胞定位 | Lysosome. |
| 组织特异性 | Tissue specificityPredominantly expressed in osteclasts (bones). |
| 相似性 | Belongs to the peptidase C1 family. |
| 功能 | Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. |
| 保存条件 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. This gene may be subject to RNA editing. [provided by RefSeq, Jul 2008]. |
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文献和实验deposit: NoPrice_code: AAvailability in cell line catalogues: ATCC CCL 61; IZSBS BS CL15; DSMZ ACC 110;Bibliographic references:J Exp Med 1958;108:945 Proc Nat Acad Sci USA 1968;60:1275CHO-K1 (hamster, Chinese, ovary)Morphology: epithelial-likeSpecies
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