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- 2025年10月15日
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| 规格： | 100ug | 产品价格： | ￥1780.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥3480.0 |
| 规格： | 20ug | 产品价格： | ￥480.0 |
| 产品编号 | bs-0388P |
| 英文名称 | Recombinant human IFN Gamma Mature Chain, C-His |
| 中文名称 | 重组人干扰素-γ/IFN-γ蛋白 |
| 英文别名 | IFNG; IFG; IFI; IFN Gamma; IFN Immune; IFN-gamma; IFNG; IFNG_HUMAN; Immune Interferon; Interferon gamma; Interferon Gamma Precursor; Macrophage Activating Factor; MAF; T Cell Interferon; Type II Interferon; hIFN-gamma; Recombinant human IFN Gamma Mature Chain, C-His |
| 性状 | Lyophilized or Liqui |
| 纯化方法 | AC |
| 理论分子量 | 16 |
| 实际分子量 | 17 kDa |
| 浓度 | ＞0.5 mg/ml |
| 储存液 | 20mM Tris-HCl (pH8.0). |
| 研究领域 | Cancer > Tumor immunology > Cytokines > Interferons Immunology > Adaptive Immunity > Regulatory T Cells Immunology > Innate Immunity > Cytokines > Interferons Stem Cells > Signaling Pathways > TGF beta > Interferon gamma |
| 亚基 | Homodimer. |
| 亚细胞定位 | Secreted. |
| 组织特异性 | Released primarily from activated T lymphocytes. |
| 翻译后修饰 | Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161. |
| 相似性 | Belongs to the type II (or gamma) interferon family. |
| 功能 | Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. |
| 保存条件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Mammalian Interferon gamma is mainly produced by T lymphocytes and NK cells. It is a pleiotropic cytokine involved in the regulation of nearly all phases of immune and inflammatory responses,including the activation, growth and differentiation of T cell, B cells, macrophages, NK cells and other cell types such as endothelial cells and fibroblasts. It has weak antiviral and antiproliferative activity, and poteniates the antiviral and anti tumor effects of IFN alpha / beta (type I interferon). It is upregulated by IL2, FGF basic, EGF and downregulated by vitamin D3 or DMN. Labile at pH 2. |
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文献和实验[IF={{ 3.222 }}] {Jing Wang. et al. Nuclear paraspeckle assembly transcript 1 promotes the podocyte injury via targeting miR-23b-3p/B-cell lymphoma-2 interacting protein 3 like axis. RENAL FAILURE. 2022 Nov 09} {Other} {}
[IF={{ 2.965 }}] {Wang Xiaolei. et al. Inhibition of miRNA-155 Alleviates High Glucose-Induced Podocyte Inflammation by Targeting SIRT1 in Diabetic Mice. J Diabetes Res. 2021;2021:5597394} {Other} {}
deposit: NoPrice_code: AAvailability in cell line catalogues: ATCC CCL 61; IZSBS BS CL15; DSMZ ACC 110;Bibliographic references:J Exp Med 1958;108:945 Proc Nat Acad Sci USA 1968;60:1275CHO-K1 (hamster, Chinese, ovary)Morphology: epithelial-likeSpecies
后置-20℃保存 20×SSC 10×PBS （DEPC处理的）含50%甲酰胺的杂交液（HS）--- 1ml分装后置-20℃保存 10×阻断液（10×BS） Buffer I Buffer II Buffer III 探针（P） 抗Dig-Ap NBT/BCIP 二、操作流程: 1） 脱蜡至水： 二甲苯5min×2 → 90%乙醇5min → DEPC水洗涤5min×2 2） 杂交前处理： 1×PBS洗涤5min → 蛋白酶K（终浓度20ug/ml in PBS）37℃
in Renal Cancer (p 73-96) Rosamonde E. Banks, Peter J. Selby Chapter 6: Heat Shock Protein 27 in Cancer (p 97-109) Dr. Cecilia Sarto, Dr. Fulvio Magni, BS. Cristina Valsecchi, Prof. Dr. Paolo Mocarelli Chapter 7: Proteomic Approaches for Biomarker
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