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- Bioss
- bs-10490R-Bio
- 2025年10月15日
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100ul
| 产品编号 | bs-10490R-Bio |
| 英文名称 | CACNA1B (N type) Rabbit pAb, Biotin conjugated |
| 中文名称 | Biotin标记的电压依赖型N型钙通道α1B抗体 |
| 英文别名 | CAC1B_HUMAN; Voltage-dependent N-type calcium channel subunit alpha-1B; Brain calcium channel III; BIII; Calcium channel, L type, alpha-1 polypeptide isoform 5; Voltage-gated calcium channel subunit alpha Cav2.2; voltage-dependent N-type calcium channel subunit alpha-1B isoform 1; calcium channel, voltage-dependent, L type, alpha; 1B subunit; voltage-dependent N-type calcium channel subunit alpha-1B; calcium channel, N type; calcium channel, voltage-dependent, alpha 1B subunit, N type; calcium channel alpha12.2 subunit; Cav2.2 voltage-gated Ca2+channel. |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500, ELISA=1:5000-10000, IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human CACNA1B (N type) |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Signal Transduction > Signaling Pathway > Calcium Signaling > Calcium Channels |
| 亚基 | Multisubunit complex consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interacts with RIMS1 and RIMBP2. |
| 亚细胞定位 | Membrane; Multi-pass membrane protein. |
| 组织特异性 | Isoform Alpha-1b-1 and isoform Alpha-1b-2 are expressed in the central nervous system, but not in skeletal muscle or aorta. |
| 翻译后修饰 | Phosphorylated in vitro by CaM-kinase II, PKA, PKC and CGPK. |
| 相似性 | Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1B subfamily.
Contains 1 EF-hand domain. |
| 功能 | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]. |
| 应用 | 推荐稀释比例 |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {ELISA} | {1:5000-10000} |
| {IF} | {1:100-500} |
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CACNA1B (N type) Rabbit pAb, Biotin conjugated(bs-10490R-Bio)-100ul
￥2980
