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- bs-0693R-BF488
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100ul
| 产品编号 | bs-0693R-BF488 |
| 英文名称 | Neuropilin 1 Rabbit pAb, BF488 conjugated |
| 中文名称 | BF488标记的神经纤毛蛋白1抗体 |
| 英文别名 | Neuropilin-1; NRP-1; Neuropilin1; BDCA4; CD 304; CD304; DKFZp686A03134; DKFZp781F1414; NEL like protein 1; Nel related protein 1; Neuropilin1; Neuropilin 1; Neuropilin1 transmembrane receptor; NP1; NRP 1; NRP; NRP1; OTTHUMP00000020818; OTTHUMP00000020820; OTTHUMP00000020821; Vascular endothelial cell growth factor 165 receptor; VEGF165R; A5 protein; BLOOD DENDRITIC CELL ANTIGEN 4; NRP1_HUMAN. |
| 产品应用 | IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human neuropilin-1 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cardiovascular > Angiogenesis > Growth Factors > VEGF > VEGF Receptors Immunology > Adaptive Immunity > Regulatory T Cells Neuroscience > Neurology process > Growth and Development > Axonal Guidance Proteins |
| 亚基 | Homodimer, and heterodimer with NRP2. Interacts with FER. Binds PLXNB1. |
| 亚细胞定位 | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. |
| 组织特异性 | The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules. |
| 相似性 | Belongs to the neuropilin family.
Contains 2 CUB domains. Contains 2 F5/8 type C domains. Contains 1 MAM domain. |
| 功能 | The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011] |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
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Neuropilin 1 Rabbit pAb, BF488 conjugated(bs-0693R-BF488)-100ul
￥2980
