ATG5/APG5L Mouse mAb, PE conjugated(bsm-33386M-PE)-100ul产品图

ATG5/APG5L Mouse mAb, PE conju

gated(bsm-33386M-PE)-100ul
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  • ￥2980
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  • bsm-33386M-PE
  • 2026年11月01日
  • 产品信息以Bioss网站为准
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    • 规格：

      100ul

    产品编号bsm-33386M-PE
    英文名称ATG5/APG5L Mouse mAb, PE conjugated
    中文名称PE标记的自噬蛋白5单克隆抗体
    英文别名ATG5; APG 5; APG 5L; APG5; APG5 autophagy 5 like; APG5 like; APG5-like; APG5L; Apoptosis specific protein; Apoptosis-specific protein; ASP; ATG 5; ATG5; ATG5 autophagy related 5 homolog; Autophagy protein 5; hAPG5; Homolog of S Cerevisiae autophagy 5; ATG5_HUMAN.
    产品应用IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Mouse
    免疫原Recombinant human ATG5 Protein
    亚型IgG
    纯化方法affinity purified by Protein G
    克隆类型Monoclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cancer > Cell Death > Apoptosis > Metabolism

    Cancer > Cell Death > Apoptosis > Phagocytosis

    Cancer > Cell Death > Autophagy > APG gene products

    Cancer > Cell Death > Autophagy > Signal Transduction

    Cancer > Signal transduction > Autophagy

    Cardiovascular > Heart > Autophagy > APG gene products

    Cell Biology > Apoptosis > Intracellular > Associated Proteins

    Cell Biology > Apoptosis > Phagocytosis

    Cell Biology > Proteolysis / Ubiquitin > Proteasome / Ubiquitin > Ub-like Proteins

    Metabolism > Pathways and Processes > Metabolism processes > Apoptosis

    Metabolism > Pathways and Processes > Metabolism processes > Autophagy and mitophagy

    Metabolism > Pathways and Processes > Metabolism processes > Autophagy and mitophagy > APG gene products

    亚基The ATG5-ATG12 conjugate forms a complex with several units of ATG16. Interacts with TECPR1; the interaction is direct and does not take place when ATG16 is associated with the ATG5-ATG12 conjugate.
    亚细胞定位Cytoplasm. Note=Colocalizes with nonmuscle actin.
    组织特异性Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells.
    翻译后修饰Conjugated to ATG12; which is essential for autophagy, but is not required for association with isolation membrane.
    相似性Belongs to the ATG5 family.
    功能Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed (By similarity). _x000D_ May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity.
    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料In yeast, autophagy is an essential process for survival during nutrient starvation and cell differentiation. The process of autophagy is characterized as a non-selective degradation of cytoplasmic proteins into membrane stuctures called autophagosomes, and it is dependent on several proteins, including the autophagy proteins APG5 and APG7. Yeast Apg7 and the human homolog, APG7, share similarities with the ubiquitin-activating enzyme E1 in Saccharomyces cerevisiae and are likewise responsible for enzymatically activating the autophagy conjugation system. Apg5 and the human homolog, APG5 (also designated apoptosis-specific protein or APS), function as substrates for the autophagy protein Apg12. These proteins are covalently bonded together to form Apg12/APG5 conjugates, which are required for the progression of autophagy.

     

    应用推荐稀释比例
    {IF}{1:100-500}

     

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    图标文献和实验
    相关实验

    • Fluorochrome Absorption and Emission Spectra

      can be affected by the mAb conjugated. Thus while in the example above the PE-conjugate is brighter than the BD Cy-Chrome™ -conjugate, when analyzed on the BD FACSCalibur™ , for many mAbs the Cy-Chrome ™ -conjugate results in a brighter stain. Contact BD

    • Fluorochrome Absorption and Emission

      can be affected by the mAb conjugated. Thus while in the example above the PE-conjugate is brighter than the BD Cy-Chrome™ -conjugate, when analyzed on the BD FACSCalibur™ , for many mAbs the Cy-Chrome ™ -conjugate results in a brighter stain. Contact BD

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