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- bs-0074R-AP
- 2025年09月30日
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100ul
| 产品编号 | bs-0074R-AP |
| 英文名称 | MAP3K14/NFkB Inducing Kinase Rabbit pAb, AP conjugated |
| 中文名称 | AP标记的NFkB诱导激酶抗体 |
| 英文别名 | MAP3K14; NF-kappaB-Inducing Kinase; NF kappa beta inducing kinase; NF-kappa-beta-inducing kinase; NFkB Inducing Kinase NIK; HS; HSNIK; NIK; Serine/threonine-protein kinase NIK; Mitogen-activated protein kinase kinase kinase 14; MAPKKK14; FTDCR1B; NF-kappa-beta-inducing kinase; M3K14_HUMAN. |
| 产品应用 | WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human NIK |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cell Biology > Apoptosis > Intracellular > Kinases Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > NFkB pathway Signal Transduction > Protein Phosphorylation > Ser / Thr Kinases > Other Kinases Signal Transduction > Signaling Pathway > Nuclear Signaling > NFkB Pathway |
| 亚基 | Interacts with TRAF2, TRAF5, TRAF6, IKKA and NFKB2/P100 (By similarity). Interacts with TRAF3 and PELI3. Interacts with NIBP; the interaction is direct. Interacts with ARRB1 and ARRB2. Interacts with GRB10. Interacts with ZFP91. |
| 亚细胞定位 | Cytoplasm. |
| 组织特异性 | Weakly expressed in testis, small intestine, spleen, thymus, peripheral blood leukocytes, prostate, ovary and colon. |
| 翻译后修饰 | Autophosphorylated. Phosphorylation at Thr-559 is required to activates its kinase activity and 'Lys-63'-linked polyubiquitination. Phosphorylated by CHUK/IKKA leading to MAP3K14 destabilization. Ubiquitinated. Undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination. 'Lys-48'-linked polyubiquitination leads to its degradation by the proteasome, while 'Lys-63'-linked polyubiquitination stabilizes and activates it. |
| 相似性 | Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily._x000D_
Contains 1 protein kinase domain. |
| 功能 | Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq]. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
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文献和实验Blotting, from protein isolation, quantification, electrophoresis, transfer and more... ・ Alkaline Phosphatase (AP) Staining of Western Blots. (Molecular Genetics RecLab) MAP Kinase Gel Shift Assay (PMCI)
TRAF‐Mediated TNFR‐Family Signaling
‐3169. Cao, Z., Henzel, W.J., and Gao, X. 1996a. IRAK: A kinase associated with the interleukin‐1 receptor. Science 271:1128‐1131.
. A role for nitroxyl anion JOURNAL J. Biol. Chem. 277 (43), 40666-40674 (2002) PUBMED 12194971 REMARK GeneRIF: role of nitroxyl anion in inducing heme oxygenase 1 REFERENCE 58 (bases 1 to 1600) AUTHORS Ke,B., Shen,X.D., Zhai,Y., Gao,F., Busuttil,R.W
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