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- bsm-33369M-AP
- 2025年09月30日
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100ul
| 产品编号 | bsm-33369M-AP |
| 英文名称 | TTR/Prealbumin Mouse mAb, AP conjugated |
| 中文名称 | AP标记的转甲状腺素蛋白/前白蛋白单克隆抗体 |
| 英文别名 | Transthyretin; Amyloid polyneuropathy; Amyloidosis I; ATTR; Dysprealbuminemic euthyroidal hyperthyroxinemia; Dystransthyretinemic hyperthyroxinemia; HsT2651; PALB; Prealbumin amyloidosis type I; Senile systemic amyloidosis; TBPA; Transthyretin; TTR; TTR protein; prealbumin; TTHY_HUMAN. |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Mouse |
| 免疫原 | Recombinant human TTR Protein |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein G |
| 克隆类型 | Monoclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cardiovascular > Blood > Serum Proteins Neuroscience > Neurology process > Neurodegenerative disease > Alzheimer's disease > Tangles & Tau |
| 亚基 | Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4. |
| 亚细胞定位 | Secreted. Cytoplasm. |
| 组织特异性 | Detected in serum and cerebrospinal fluid (at protein level). Highly expressed in choroid plexus epithelial cells. Detected in retina pigment epithelium and liver. |
| 翻译后修饰 | Not glycosylated under normal conditions. Following unfolding, caused for example by variant AMYL-TTR 'Gly-38', the cryptic Asn-118 site is exposed and glycosylated by STT3B-containing OST complex, leading to its degradation by the ER-associated degradation (ERAD) pathway. |
| 相似性 | Belongs to the transthyretin family. |
| 功能 | Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. [provided by RefSeq] |
| 应用 | 推荐稀释比例 |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
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文献和实验Mouse Models of Bariatric Surgery
., and Peterfy, M. 2006. Genetic analysis of the diabetes‐prone C57BLKS/J mouse strain reveals genetic contribution from multiple strains. Biochim. Biophys. Acta 1762:440‐446. Phillips
Developing Genetically Engineered Mouse Models to Study Tumor Suppression
transgene but not its random or imprinted X inactivation. Proc. Natl. Acad. Sci. U.S.A. 103:9958‐9963. Clarke, A.R., Maandag, E.R., van Roon, M., van der Lugt, N.M., van der Valk
pathogen recognition receptor proteins known as Toll-like receptors (TLRs), or by treatment with certain cytokines. Recent microarray studies have shown that one consequence of activation of mouse macrophages is an increased accumulation
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