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- Bioss
- bs-2431R-APC
- 2025年09月30日
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100ul
| 产品编号 | bs-2431R-APC |
| 英文名称 | TNFSF13B Rabbit pAb, APC conjugated |
| 中文名称 | APC标记的肿瘤坏死因子配体超家族成员13B抗体 |
| 英文别名 | Tumor necrosis factor ligand superfamily member 13B; B lymphocyte stimulator; BLyS; B-cell-activating factor; B cell Activating Factor; B lymphocyte stimulator; ApoL related ligand TALL 1; BAFF; delta BAFF; Dendritic cell-derived TNF-like molecule; TNF-and APOL-related; eukocyte expressed ligand 1; TALL-1; CD257; CD 257; CD257 antigen; Tumor necrosis factor ligand superfamily member 13b, membrane form; Tumor necrosis factor ligand superfamily member 13b, soluble form; ZTNF4; TN13B_MOUSE; TN13B_HUMAN. |
| 产品应用 | Flow-Cyt=3μg/Test Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from mouse TNFSF13B |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Growth factors > TNF Cell Biology > Apoptosis > Extracellular Signals > Death Ligands Immunology > Adaptive Immunity > B Cells > Non-CD Immunology > Innate Immunity > Cytokines > Necrosis Factors |
| 亚基 | Belongs to the tumor necrosis factor family. |
| 亚细胞定位 | Secreted and Cell membrane. |
| 组织特异性 | Abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T-cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas. |
| 翻译后修饰 | The soluble form derives from the membrane form by proteolytic processing. Isoform 2 is not efficiently shed from the membrane unlike isoform 1. |
| 相似性 | Belongs to the tumor necrosis factor family. |
| 功能 | Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B-and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. [provided by RefSeq]. |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {3μg/Test} |
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文献和实验Fluorochrome Absorption and Emission Spectra
light at 488 nm for three-color flow cytometric analysis (Fig. 1). BD Biosciences Pharmingen also offers monoclonal antibodies and proteins conjugated to allophycocyanin (APC) and avidin conjugated to Texas Red™. Both of these dyes
Fluorochrome Absorption and Emission
for three-color flow cytometric analysis (Fig. 1). BD Biosciences Pharmingen also offers monoclonal antibodies and proteins conjugated to allophycocyanin (APC) and avidin conjugated to Texas Red™. Both of these dyes are useful in experiments
区、1个IgC样区、1个跨膜疏水区和1个由30个氨基酸组成的胞内区。不同于其他B7家族分子的是，它具有负向调节免疫应答的作用。PD-1和PD-L1是一对共抑制分子[3]。 这对共抑制分子，对癌细胞是如何发挥作用的呢。 憋急，听我慢慢道来！ 人类身体健康的卫士「T细胞」的活化是需要接收「双重信号」的：首先，T细胞表面受体（TCR）识别由抗原提呈细胞（APCs）提呈的抗原肽，使T细胞初步活化；然后，APC表面的共刺激分子与T细胞表面的相应共刺激分子结合，使T
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