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- bsm-30106M-PE-Cy7
- 2025年09月30日
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产品信息以Bioss网站为准
- 规格：
25T/50T/100T
| 规格： | 25T | 产品价格： | ￥1380.0 |
|---|---|---|---|
| 规格： | 50T | 产品价格： | ￥2280.0 |
| 规格： | 100T | 产品价格： | ￥3880.0 |
| 产品编号 | bsm-30106M-PE-Cy7 |
| 英文名称 | CD146 Mouse mAb, PE-Cy7 conjugated |
| 中文名称 | PE-Cy7标记的黑色素瘤细胞粘附分子CD146单克隆抗体 |
| 英文别名 | A32 antigen; MCAM; Melanoma adhesion molecule; Melanoma associated antigen A32; Melanoma cell adhesion molecule; MelCAM; MUC18; Sendo1; MUC18_HUMAN. |
| 中文别名 | CD 146; Cell surface glycoprotein MUC18; Cell surface glycoprotein P1H12; S endo 1; S endo 1 endothelial associated antigen; Sendo 1 endothelial associated antigen; MUC 18; CD146 antigen; Melanoma associated antigen MUC18; Melanoma associated glycoprotein MUC18; |
| 产品应用 | Flow-Cyt=10ul/Test Not yet tested in other applications. |
| 抗体来源 | Mouse |
| 免疫原 | KLH conjugated synthetic peptide derived from human CD146 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein G |
| 克隆类型 | Monoclonal |
| 储存液 | 0.01M PBS (pH7.4), 0.5% BSA, 0.02% Proclin300. |
| 研究领域 | Cancer > Invasion/microenvironment > ECM > Cell adhesion Cardiovascular > Angiogenesis > Endothelial Cell Markers Immunology > Cell Type Markers > CD > Endothelial Cells Signal Transduction > Cytoskeleton / ECM > Cell Adhesion > Cell Adhesion Molecules > Endothelial Stem Cells > Endothelial Progenitors > Endothelial Markers |
| 亚细胞定位 | Membrane; Single-pass type I membrane protein. |
| 组织特异性 | Detected in endothelial cells in vascular tissue throughout the body. May appear at the surface of neural crest cells during their embryonic migration. Appears to be limited to vascular smooth muscle in normal adult tissues. Associated with tumor progression and the development of metastasis in human malignant melanoma. Expressed most strongly on metastatic lesions and advanced primary tumors and is only rarely detected in benign melanocytic nevi and thin primary melanomas with a low probability of metastasis. |
| 相似性 | Contains 3 Ig-like C2-type (immunoglobulin-like) domains. _x000D_ Contains 2 Ig-like V-type (immunoglobulin-like) domains. |
| 功能 | Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. |
| 保存条件 | Store at 2-8℃. Protect from light. Avoid freezing. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | MCAM (MUC18 antigen, CD146), a member of the immuoglobulin superfamily, is an intrinsic membrane glycoprotein of 110-120 kDa found on the surface of endothelial cells, bone marrow fibroblasts and various melanomas. MCAM (Melanoma adhesion molecule) has been used as a marker of tumor progression in human melanoma because expression in those tumors correlates strongly with poor prognosis and the development of metastic disease. In addition, a number of human T, B and myeloid leukemic cell lines seem to express MCAM. The close structural relationship with N-CAM and related molecules suggests that MCAM may be also a developmentally regulated cell adhesion. |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {10ul/Test} |
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CD146 Mouse mAb, PE-Cy7 conjugated(bsm-30106M-PE-Cy7)-25T/50T/100T
￥1380 - 3880
