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- bs-23896R-AP
- 2025年09月30日
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100ul
| 产品编号 | bs-23896R-AP |
| 英文名称 | HNF-1α Rabbit pAb, AP conjugated |
| 中文名称 | AP标记的肝细胞核因子1α抗体 |
| 英文别名 | HNF1A; TCF1; HNF1 alpha; HNF-1 alpha; Hepatocyte nuclear factor 1 alpha; Albumin proximal factor; Hepatic nuclear factor 1 alpha; Hepatic nuclear factor 1; Hepatic transcription factor 1 alpha; Hepatic transcription factor 1; HNF 1; HNF 1A; HNF1A; Interferon production regulator factor; LF B1; LF B1 hepatic nuclear factor; LFB 1; LFB1; LFB1 hepatic nuclear factor; Liver specific transcription factor LF B1; Liver specific transcription factor LFB1; Maturity onset diabetes of the young 3; MODY 3; MODY3; TCF 1; TCF1; TCF-1; Transcription factor 1; Transcription factor 1 hepatic; HNF1A_HUMAN. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human HNF-1α |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Epigenetics and Nuclear Signaling > Transcription > Other factors Epigenetics and Nuclear Signaling > Transcription > Transcription Factors |
| 亚基 | Binds DNA as a dimer. Interacts with PCBD1. Heterotetramer with PCBD1; formed by a dimer of dimers. |
| 亚细胞定位 | Nucleus. [ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named isoforms=3; Name=A; IsoId=P20823-1; Sequence=Displayed; Name=B; IsoId=P20823-2; Sequence=VSP_002250, VSP_002251; Name=C; IsoId=P20823-3; Sequence=VSP_002252, VSP_002253. |
| 组织特异性 | Liver. |
| 相似性 | Belongs to the HNF1 homeobox family. Contains 1 homeobox DNA-binding domain. |
| 功能 | Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Required for the expression of several liver specific genes. Binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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文献和实验Immunofluorescence: Rabbit Anti-Murine RELMα
for 25 minutes. 3. Incubate the tissue section with blocking buffer for 20 minutes. 4. Incubate the tissue section overnight at 4?C with Rabbit Anti-Murine RELMα at 4.0 ng/mL in 1X PBS with 0.01% Triton-X and 0.5% BSA. Wash the slide
nonlymphocytic leukemia,ANLL)、顽固性巨幼红细胞 贫血 等疾病的发病有关。 3.IL-3受体 分子量为140kDa，属于红细胞生成素受体超家族成员，而且具有2个该家族的结构域，IL-3R胞浆区是酪氨酸激酶的底物。有关IL-3Rβ链参见本节GM-CSF受体和本章第三节。 4.IL-3的生物学活性 IL-3与其它集落刺激因子的生物学作用见表4-4。除具有多重集落刺激作用外，最近发现IL-3可刺激皮肤上皮细胞、CD4-CD8-TCRαβ细胞、肥大细胞、嗜
= NAL), appears to form upon oxidative cyclization of the nonfluorescent 2:1 lysine-HNE Michael adduct-Schiff base cross-link (Scheme 1). Polyclonal antibody (PAb) to the NAL-HNE fluorophore was raised in rabbit and found to be highly specific
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