ITGAV&ITGB6 Rabbit pAb, BF350 conj.(bs-5791R-BF350)-100ul产品图

ITGAV&ITGB6 Rabbit pAb, BF350

conj.(bs-5791R-BF350)-100ul
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  • bs-5791R-BF350
  • 2026年10月14日
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    北京博奥森生物技术有限公司
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      100ul

    产品编号bs-5791R-BF350
    英文名称Integrin Alpha V + Beta 6 Rabbit pAb, BF350 conjugated
    中文名称BF350标记的整合素αVβ6抗体
    英文别名Integrin alpha 5 beta 6; CD51; Integrin alpha-V light chain; integrin, alpha V(vitronectin receptor, alpha polypeptide, antigen CD51); Integrin, alpha V; Integrin, beta 6; ITAV_HUMAN; ITGAV; ITGB6; Vitronectin receptor subunit alpha.
    产品应用Flow-Cyt=1μg/Test, IF=1:100-500, ICC/IF=1:50-200

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human Integrin Alpha V + Beta 6
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cardiovascular > Angiogenesis > Adhesion / ECM > Integrins

    Cardiovascular > Atherosclerosis > Vascular Inflammation > Leukocyte recruitment > Integrins

    Cardiovascular > Blood > Platelets

    Microbiology > Interspecies Interaction > Host Virus Interaction

    Stem Cells > Hematopoietic Progenitors > Lymphoid > T Lymphocytic Lineage

    亚基Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8 subunit. Interacts with HIV-1 Tat. Alpha-V/beta-6 binds to foot-and-mouth disease virus (FMDV) VP1 protein and acts as a receptor for this viru. Alpha-V/beta-6 binds to coxsackievirus A9 and coxsackievirus B1 capsid proteins and acts as a receptor for these viruses. Interacts with RAB25.
    亚细胞定位Cell Membrane
    相似性Belongs to the integrin alpha chain family.
    Contains 7 FG-GAP repeats.
    功能The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metatastatic diffusion of tumour cells. ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; ITGB1, ITGB3, ITGB5, ITGB6, and ITGB8), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction.

     

    应用推荐稀释比例
    {Flow-Cyt}{1μg/Test}
    {IF}{1:100-500}
    {ICC/IF}{1:50-200}

     

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      5DcKyZhPRCAiEBGICEQE9nEEAjlmlbyw0EeoEtpbJt95QMPcL9MIebnA1VtD7t1YSTtXyMtDhcwzGhmZUGipbKmgJ40ebbfd9FORapFkrT5SF8FFMy26mwSZZpjsl62y1R5dfIeVuzfLdGO0Vh7UqoDlbussKp9M3R5cfLcSqUyR5Ka0y6i7ocUQGX7xnBHkJ+PBZJ/jGCIC/14EIkn+9yIW40cEIgIRgYhARGC/R+C16UHi+q1p/T3dWhUwbwuu/IF7uWjRRD

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