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- bs-1031R-Bio
- 2025年09月30日
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100ul
| 产品编号 | bs-1031R-Bio |
| 英文名称 | IFITM1 Rabbit pAb, Biotin conjugated |
| 中文名称 | Biotin标记的干扰素诱导跨膜蛋白1抗体 |
| 英文别名 | CD225; CD225 antigen; CD 225; CD-225; IFI17; Interferon induced protein 17; Interferon induced transmembrane protein 1; Interferon inducible protein 9-27; Interferon-induced protein 17; Interferon-induced transmembrane protein 1; Interferon-inducible protein 9-27; Leu 13 antigen; Leu-13 antigen; LEU13; IFM1_HUMAN; Dispanin subfamily A member 2a; DSPA2a. |
| 产品应用 | ELISA=1:5000-10000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human IFITM1 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Oncoproteins/suppressors > Tumor suppressors > p53 pathway Cancer > Tumor biomarkers Immunology > Innate Immunity > Cytokines > Interferons Signal Transduction > Adapters > Transmembrane Stem Cells > Signaling Pathways > TGF beta > Interferon gamma Stem Cells > Signaling Pathways > Wnt > Surface Molecules |
| 亚基 | Interacts with CAV1; this interaction enhances the ability of CAV1 in inhibiting ERK activation. |
| 亚细胞定位 | Cell membrane; Multi-pass membrane protein. |
| 翻译后修饰 | Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity against influenza virus. |
| 相似性 | Belongs to the CD225 family. |
| 功能 | IFN-induced antiviral protein that mediate cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus, and dengue virus by inhibiting the early step(s) of replication. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Implicated in the control of cell growth. Component of a multimeric complex involved in the transduction of antiproliferative and homotypic adhesion signals. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | IFITM1 expression is induced by interferons alpha and gamma and it is thought to play a role in control of cell growth. It is upregulated in several tumor types and may be useful as a tumor biomarker. |
| 应用 | 推荐稀释比例 |
| {ELISA} | {1:5000-10000} |
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文献和实验- or triple-labeling immunofluorescence, it is necessary to use primary antibodies raised in different host species such as mouse, rabbit, and goat. However, in many cases, suitable primary antibodies raised in different species are unavailable
Attachment of Reporter and Conjugate Groups to the 3′ Termini of Oligonucleotides
‐lysine) conjugates: Mechanism of cell uptake. Bioconjugate Chem. 1:149‐153. Letsinger, R.L., Zhang, G., Sun, D.K., Ikeuchi, T., and Sarin, P.S. 1989. Cholesteryl‐conjugated
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